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Table 2 Subgroup meta-analyses of the association between MUC1 polymorphism rs4072037 and gastric cancer risk under the allele model

From: MUC1 gene polymorphism rs4072037 and susceptibility to gastric cancer: a meta-analysis

Comparison No. of datasets Case Control OR (95% CI) P for OR P for heterogeneity I2(%) Model
Overall 12 10410 11437 0.70 (0.64,0.76) <0.00001 0.04 47 Random
Anatomic location         
Cardia gastric cancer 5 2362 7426 0.75(0.62,0.91) 0.004 0.04 63 Random
Non-cardia gastric caner 5 5161 7426 0.66 (0.58,0.74) <0.00001 0.15 43 Fixed
Pathological subtype         
Diffuse-type gastric cancer 6 1756 5191 0.65 (0.57,0.73) <0.00001 0.29 19 Fixed
Intestinal-type gastric cancer 4 1727 3354 0.75 (0.66,0.83) <0.00001 0.48 0 Fixed
Ethnicity         
Asian 10 9826 10853 0.69 (0.63,0.75) <0.00001 0.05 47 Random
Caucasion 2 584 584 0.76 (0.56,1.04) 0.08 0.07 70 Random
Sample size         
>1000 6 8652 9614 0.73(0.69,0.78) <0.00001 0.10 45 Fixed
≤1000 6 1758 1823 0.66 (0.59,0.75) <0.00001 0.10 47 Fixed
Quality score         
>7 5 6183 5742 0.73 (0.65,0.82) <0.00001 0.27 23 Fixed
≤7 7 4227 5695 0.69 (0.64,0.75) <0.00001 0.22 28 Fixed
Control source         
Hospital-based 7 2683 3958 0.65 (0.59,0.72) <0.00001 0.16 35 Fixed
Population-based 5 7727 7479 0.75 (0.70,0.81) <0.00001 0.19 34 Fixed
Adjustment         
Yes 9 9688 10612 0.69 (0.63,0.76) <0.00001 0.04 51 Random
No 3 722 825 0.74 (0.63,0.86) 0.0001 0.13 51 Fixed
Statistical power         
≥0.8 6 5595 8620 0.67(0.62, 0.72) <0.00001 0.22 0.29 Fixed
<0.8 6 4815 4081 0.78(0.72,0.85) <0.00001 0.27 0.22 Fixed
  1. OR, odds ratio; CI, confidence interval.