Table 2 Subgroup meta-analyses of the association between MUC1 polymorphism rs4072037 and gastric cancer risk under the allele model
From: MUC1 gene polymorphism rs4072037 and susceptibility to gastric cancer: a meta-analysis
Comparison | No. of datasets | Case | Control | OR (95% CI) | P for OR | P for heterogeneity | I2(%) | Model |
|---|---|---|---|---|---|---|---|---|
Overall | 12 | 10410 | 11437 | 0.70 (0.64,0.76) | <0.00001 | 0.04 | 47 | Random |
Anatomic location | ||||||||
Cardia gastric cancer | 5 | 2362 | 7426 | 0.75(0.62,0.91) | 0.004 | 0.04 | 63 | Random |
Non-cardia gastric caner | 5 | 5161 | 7426 | 0.66 (0.58,0.74) | <0.00001 | 0.15 | 43 | Fixed |
Pathological subtype | ||||||||
Diffuse-type gastric cancer | 6 | 1756 | 5191 | 0.65 (0.57,0.73) | <0.00001 | 0.29 | 19 | Fixed |
Intestinal-type gastric cancer | 4 | 1727 | 3354 | 0.75 (0.66,0.83) | <0.00001 | 0.48 | 0 | Fixed |
Ethnicity | ||||||||
Asian | 10 | 9826 | 10853 | 0.69 (0.63,0.75) | <0.00001 | 0.05 | 47 | Random |
Caucasion | 2 | 584 | 584 | 0.76 (0.56,1.04) | 0.08 | 0.07 | 70 | Random |
Sample size | ||||||||
>1000 | 6 | 8652 | 9614 | 0.73(0.69,0.78) | <0.00001 | 0.10 | 45 | Fixed |
≤1000 | 6 | 1758 | 1823 | 0.66 (0.59,0.75) | <0.00001 | 0.10 | 47 | Fixed |
Quality score | ||||||||
>7 | 5 | 6183 | 5742 | 0.73 (0.65,0.82) | <0.00001 | 0.27 | 23 | Fixed |
≤7 | 7 | 4227 | 5695 | 0.69 (0.64,0.75) | <0.00001 | 0.22 | 28 | Fixed |
Control source | ||||||||
Hospital-based | 7 | 2683 | 3958 | 0.65 (0.59,0.72) | <0.00001 | 0.16 | 35 | Fixed |
Population-based | 5 | 7727 | 7479 | 0.75 (0.70,0.81) | <0.00001 | 0.19 | 34 | Fixed |
Adjustment | ||||||||
Yes | 9 | 9688 | 10612 | 0.69 (0.63,0.76) | <0.00001 | 0.04 | 51 | Random |
No | 3 | 722 | 825 | 0.74 (0.63,0.86) | 0.0001 | 0.13 | 51 | Fixed |
Statistical power | ||||||||
≥0.8 | 6 | 5595 | 8620 | 0.67(0.62, 0.72) | <0.00001 | 0.22 | 0.29 | Fixed |
<0.8 | 6 | 4815 | 4081 | 0.78(0.72,0.85) | <0.00001 | 0.27 | 0.22 | Fixed |