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Figure 2

From: Epstein–Barr virus-associated posttransplant lymphoproliferative disorder involving the central nervous system following autologous hematopoietic stem cell transplantation for neuroblastoma

Figure 2

Histological analysis of the brain tumor demonstrated an abnormal infiltration of pleomorphic lymphoid cells with a dominant component of large lymphoid cells (A; hematoxylin-eosin stain). Nuclear expressions for Epstein–Barr virus (EBV) nuclear antigen 2 (EBNA-2) and EBV-encoded RNA 1 (EBER1) were detected with immunohistochemistry (B) and in situ hybridization (C), respectively. The pathological diagnosis was diffuse large B-cell lymphoma with latency type III, EBV-infection.

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