Figure 4From: Increased expression of CYP17A1 indicates an effective targeting of the androgen receptor axis in castration resistant prostate cancer (CRPC)AR targeting siRNA in VCaP: siRNA against AR significantly reduced AR expression and an up-regulation of CYP17A1 expression in the absence of AA. No such effect is seen in AKR1C3 mRNA expression levels (A-D); (*= p < 0.05, **= p < 0.005 and ***= p < 0.0005).Back to article page