Figure 2From: Increased expression of CYP17A1 indicates an effective targeting of the androgen receptor axis in castration resistant prostate cancer (CRPC)Expression profile of CYP17A1 and AKR1C3: CYP17A1 expression level is significantly increased in VCaP and LNCaP after treatment with 25 μm AA (A + B). In addition AKR1C3 mRNA is decreased in VCaP and increased in LNCaP cell line (C + D); (*= p < 0.05, **= p < 0.005 and ***= p < 0.0005).Back to article page