Figure 4From: Differential regulation of c-Met signaling pathways for synovial cell functionEffects of blocking c-Met signaling on the production of MMP-3, VEGF, and PGE2 by MH7A cells. A. MH7A cells (2 x 104 cells/well) were cultured with or without either NK4 or SU11274 in the presence or absence of 100 ng/ml TNF-α. After 72 hours of incubation, MMP-3, VEGF and PGE2 production was determined by analysis of supernatants using ELISA. B. MH7A cells (2 x 104 cells/well) were cultured with different dose of SU11274 in the presence or absence of 100 ng/ml TNF-α. After 72 hours of incubation, MMP-3, VEGF and PGE2 production was determined by analysis of supernatants using ELISA. Data represent the mean ± SD of three independent experiments. *P < 0.01. NS, not significant.Back to article page