Relationship of NPi scores and pupillary asymmetry in the acute treatment course. Patient one’s initial eight hour pupillary function time-course, post traumatic brain injury, in the NeuroTrauma intensive care unit. Her right NPi scores (A) gradually improved from 0.5 to 1.2, while her left NPi scores stayed within normal ranges. Her pupillary asymmetries (B) over the same time frame remained significantly different. Initial improvement in her right NPi scores guided an observational treatment paradigm over neurosurgical invasive therapies.