Prognostic significance of histological invasion in high grade soft tissue sarcomas

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Table 1 Clinicopathological data for 133 patients with non-small round cell high grade soft tissue sarcomas

Characteristics	All	%	With invasion	Without invasion	P-value**
	(N = 133)		(N = 52)	(N = 81)
Age
Median	62 yr
<60 yr	56	42	16	38
≧60 yr	77	58	36	43	p = 0.064
Gender
Male	78	59	32	46	p = 0.587
Female	55	41	20	35
Tumor location
Upper extremity	23	17	11	12
Lower extremity	85	64	28	56
Trunk	25	19	13	12	p = 0.142
Tumor depth
Superficial	62	47	13	49
Deep	71	53	39	32	p < 0.05
Tumor size
≦5 cm	46	35	11	35
>5 cm	87	65	41	46	p = 0.009
Surgical margin
R0	122	92	39	74
R1	11	8	13	7	p < 0.05
R2	0	0	0	0
Histological diagnosis
Undifferentiated pleomorphic sarcoma	52	39	31	21	p = 0.01
Liposarcoma	23	17	4	19
Myxofibrosarcoma	14	11	3	11
MPNST*	14	11	5	9
Synovial sarcoma	13	10	4	9
Leiomyosarcoma	10	8	3	7
Other	7	5	2	5
Continuously free of disease	82	62	22	60
Alive with disease	8	6	4	4
Alive and currently no evidence of disease	18	14	10	8
Dead of disease	22	17	14	8
Dead of other disease	3	2	2	1
Overall survival rate at 5 years	82.2%		69.6%	90.3%
Event-free survival rate at 5 years	63.6%		41.3%	77.5%
Metastasis-free survival rate at 5 years	69.8%		53.0%	80.8%
Local recurrence-free rate at 5 years	86.8%		77.8%	92.1%

*MPNST; malignant peripheral nerve sheath tumor.
**The risk factor of invasion was assessed using Fisher's exact test or the Chi-square test.