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Figure 2

From: Changes to signal peptide and the level of transforming growth factor- β1 due to T869C polymorphism of TGF β1 associated with lupus renal fibrosis

Figure 2

The T869C polymorphism changes the structure and properties of the TGFβ1 signal peptide. The polymorphism changes Leucine (A1) to Proline (A2) that breaks the helix structure that alters the interaction of TGFβ1 signal peptides (green) with Signal Recognition Particle (SRP; red) and translocon (gray) (A3 and A4). The proline type of TGFβ1 signal peptide reduces the values on transmembrane tendency (B2) and bind more stably to the protein partner (C).

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