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Table 1 Clinical characteristics of 25 patients with RA aortitis

From: Rheumatoid arthritis-associated aortitis: a case report and literature review

Case Ref Age/Sex Disease duration of RA Extra-aortic involvement of arteritis Pathology of Aortitis Rheumatoid nodule RF Type of HLA RA treatment Aortitis treatment
Granuloma Giant cells Atherosclerosis
1 6 68/F ND ND + ND ND ND NSAIDs NSAIDs
2 6 71/F ND ND + + ND ND ND NSAIDs NSAIDs
3 7 63/F 23 ND ND + ND + ND ND Steroid
4 7 65/F 10 ND ND ND + + + ND ND Steroid
5 8 16/F 0 + ND ND ND ND Steroid NSAIDs
6 9 49/F 5 + + + + + ND NSAIDs, Gold, PSL Digitalis
7 10 37/F −11* ND ND ND + + DR4 NSAIDs, CQ, Gold PSL 40 mg
8 11 53/F 0 + ND ND ND ND NSAIDs, HCQ PSL 60 mg
9 12 50/F 0 + ND NSAIDs
10 13 46/M 9 + + + + ND Aspirin
11 13 52/F 26 + + + + ND Steroid, Aspirin
12 13 60/M 12 + + + + ND Steroid, HCQ, Gold, CYC
13 13 61/F 11 + + + + ND Steroid, Gold, Aspirin High-dose steroid
14 13 61/F 3 + + + + ND Steroid, HCQ, Gold
15 13 64/F 3 + + + + ND Steroid, HCQ, Gold
16 13 67/M 2 + + + + ND Steroid
17 13 68/M 21 + + + + + ND Steroid, HCQ
18 13 69/M 1 + + + + + ND Steroid, Gold, SASP
19 13 82/F 8 + ND Steroid, HCQ Low-dose steroid
20 14 44/M ND + ND ND ND + + ND Steroid, SASP PSL 100 mg, IVCY 5 mg/kg
21 15 64/F 4 ND ND + + + DR2,12(5) ND PSL 10 mg
22 16 36/F 2 ND ND ND ND + DR4,1 SASP, MTX PSL 50 mg
23 17 49/F 1 ND ND ND + ND Steroid, MTX, LEF PSL 40 mg, bosentan
24 18 43/F ND ND ND ND + ND MTX, ADA mPSL 250 mg, PSL 40 mg
25 Present case 73/F 4 + ND ND + + B51, B52 SASP, TAC PSL 30 mg
  1. Abbreviations: M male, F female, + positive, negative, RA rheumatoid arthritis, RF rheumatoid factor, HLA human leukocyte antigen, ND not described, NSAIDs non-steroidal anti-inflammatory drugs, PSL prednisolone, mPSL methylprednisolone, CYC cyclophosphamide, CQ chloroquine, HCQ hydroxychloroquine, SASP salazosulfapyridine, LEF leflunomide, MTX methotrexate, ADA adalimumab, TAC tacrolimus, IVCY intravenous cyclophosphamide, ND not described.
  2. *The RA developed 11 years after the aortitis.