Table 3 Side-effects and therapeutic interventions according to regimen Side effects according to the WHO scale were compared in a matched pair analysis
Effects | 6xCIVEP-14 | 6xCHOEP-14 | p-vlaue |
|---|---|---|---|
Hematotoxicty* | % pts. | % pts. | |
Leukocytopenia (<1*10³/mm³) | 80.0 | 39.1 | <0.001 |
Thrombocytopenia (<50*10³/mm³) | 57.5 | 31.6 | =0.021 |
(<8 g/dl) | 74.5 | 35.8 | <0.001 |
Side effects WHO Grade III-IV | |||
Alopecia | 61.8 | 67.9 | n.s. |
Infection | 14.5 | 11.1 | n.s. |
ANE | 10.9 | 5.5 | n.s. |
Polyneuropathy | 7.3 | 3.7 | n.s. |
Pulmonary toxicity | 7.3 | 3.7 | n.s. |
Cardiotoxicity | 5.5 | 3.7 | n.s. |
Renal toxicity | 0.0 | 1.9 | n.s. |
Therapeutic interventions (per patient) | % | % | |
Red blood transfusion | 69.1 | 38.2 | =0.001 |
Platelet transfusion | 18.2 | 5.5 | =0.039 |
Antibiotics | 54.5 | 41.8 | =0.182 |