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Table 2 Genotypes and allele frequencies for VKORC1 G-1639A and CYP2C9 A1075C obtained by PCR-CTPP

From: A PCR method for VKORC1 G-1639A and CYP2C9 A1075C genotyping useful to warfarin therapy among Japanese

Gene

N

Frequency (%)

Allele frequency

Hardy-Weinberg equilibriump

VKORC1 (rs9923231, c.-1639G > A)

     

 Nagoya

     

GG

2

0.5

G

0.085

0.514

GA

68

16.0

A

0.915

 

AA

356

83.5

   

Total

a426

100

   

CYP2C9 (rs1057910, c.1075A > C)

     

 Nagoya

     

AA (*1*1)

414

95.8

*1

0.979

0.658

AC (*1*3)

18

4.2

*3

0.021

 

CC (*3*3)

0

0

   

Total

b432

100

   
  1. CYP = Cytochrome P450, PCR-CTPP = Polymerase chain reaction with confronting two-pair primers, VKORC1 = Vitamin K epoxide reductase complex, subunit 1.
  2. aData was missing for 10 subjects with unsuccessful genotyping.
  3. bFour were failed.