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Table 2 Genotypes and allele frequencies for VKORC1 G-1639A and CYP2C9 A1075C obtained by PCR-CTPP

From: A PCR method for VKORC1 G-1639A and CYP2C9 A1075C genotyping useful to warfarin therapy among Japanese

Gene N Frequency (%) Allele frequency Hardy-Weinberg equilibriump
VKORC1 (rs9923231, c.-1639G > A)      
 Nagoya      
GG 2 0.5 G 0.085 0.514
GA 68 16.0 A 0.915  
AA 356 83.5    
Total a426 100    
CYP2C9 (rs1057910, c.1075A > C)      
 Nagoya      
AA (*1*1) 414 95.8 *1 0.979 0.658
AC (*1*3) 18 4.2 *3 0.021  
CC (*3*3) 0 0    
Total b432 100    
  1. CYP = Cytochrome P450, PCR-CTPP = Polymerase chain reaction with confronting two-pair primers, VKORC1 = Vitamin K epoxide reductase complex, subunit 1.
  2. aData was missing for 10 subjects with unsuccessful genotyping.
  3. bFour were failed.
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