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Table 3 Longitudinal changes in patient VBM values

From: A prospective study of grey matter and cognitive function alterations in chemotherapy-treated breast cancer patients

  Pre-chemo to 1-month post (n = 19) Pre-chemo to 1-year post (n = 19) 1-month post to 1-year post (n = 19)
Regions Mean ∆ T value p value Mean ∆ T value p value Mean ∆ T value p value
Composite Whole-Brain -909.08 ± 162.64 -11.70 <0.001 -387.78 ± 164.58 -4.95 <0.001 535.88 ± 186.53 6.04 <0.001
Left Hemisphere          
Medial Orbitofrontal Gyrus -5.85 ± 3.11 -3.94 0.003 -2.52 ± 3.59 -1.474 0.158 3.63 ± 4.17 1.83 0.130
Inferior Orbitofrontal Gyrus -9.62 ± 4.29 -4.69 <0.001 -3.62 ± 4.75 -1.61 0.125 6.40 ± 4.29 3.13 0.008
Inferior Frontal Operculum -26.21 ± 11.68 -4.70 <0.001 -15.70 ± 10.29 -3.20 0.007 12.38 ± 14.28 1.82 0.085
Middle Temporal Gyrus -95.23 ± 40.65 -4.90 <0.001 -48.55 ± 74.59 -1.37 0.188 47.47 ± 65.50 1.52 0.152
Insular Cortex -20.91 ± 8.48 -5.16 <0.001 -16.14 ± 11.29 -3.00 0.011 4.82 ± 11.29 0.90 0.381
Superior Temporal Gyrus -79.35 ± 29.94 -5.55 <0.001 -40.30 ± 24.20 -3.50 0.004 42.86 ± 27.16 3.32 0.004
Anterior Cingulate -15.49 ± 5.14 -6.30 <0.001 -8.87 ± 8.08 -2.31 0.033 5.83 ± 9.04 1.36 0.192
Calcarine Cortex -3.70 ± 1.80 -4.41 <0.001 -0.43 ± 2.35 -0.39 0.703 3.11 ± -2.18 2.99 0.011
Right Hemisphere          
Middle Frontal Gyrus -8.30 ± 3.70 -4.70 <0.001 -4.97 ± 3.26 -3.20 0.007 3.92 ± 4.52 1.82 0.085
Gyrus Rectus -29.36 ± 12.97 -4.74 <0.001 -3.99 ± 21.89 -0.38 0.706 24.03 ± 20.51 2.46 0.036
Paracentral Lobule -34.50 ± 14.91 -4.84 <0.001 -18.34 ± 21.67 -1.78 0.092 17.40 ± -16.53 2.21 0.060
Precuneus -6.89 ± 2.61 -5.53 <0.001 -5.61 ± 5.84 -2.02 0.089 0.80 ± 6.17 0.27 0.788
Hippocampus -11.41 ± 3.63 -6.58 <0.001 -7.89 ± 5.71 -2.91 0.014 3.01 ± 5.11 1.24 0.232
Anterior Cingulate -11.20 ± 4.88 -4.80 <0.001 -4.99 ± 5.74 -1.82 0.100 5.42 ± 6.53 1.74 0.100
  1. Units are mm3; Mean ∆: mean difference ± 95% confidence interval.