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Table 3 Longitudinal changes in patient VBM values

From: A prospective study of grey matter and cognitive function alterations in chemotherapy-treated breast cancer patients

 

Pre-chemo to 1-month post (n = 19)

Pre-chemo to 1-year post (n = 19)

1-month post to 1-year post (n = 19)

Regions

Mean ∆

T value

p value

Mean ∆

T value

p value

Mean ∆

T value

p value

Composite Whole-Brain

-909.08 ± 162.64

-11.70

<0.001

-387.78 ± 164.58

-4.95

<0.001

535.88 ± 186.53

6.04

<0.001

Left Hemisphere

         

Medial Orbitofrontal Gyrus

-5.85 ± 3.11

-3.94

0.003

-2.52 ± 3.59

-1.474

0.158

3.63 ± 4.17

1.83

0.130

Inferior Orbitofrontal Gyrus

-9.62 ± 4.29

-4.69

<0.001

-3.62 ± 4.75

-1.61

0.125

6.40 ± 4.29

3.13

0.008

Inferior Frontal Operculum

-26.21 ± 11.68

-4.70

<0.001

-15.70 ± 10.29

-3.20

0.007

12.38 ± 14.28

1.82

0.085

Middle Temporal Gyrus

-95.23 ± 40.65

-4.90

<0.001

-48.55 ± 74.59

-1.37

0.188

47.47 ± 65.50

1.52

0.152

Insular Cortex

-20.91 ± 8.48

-5.16

<0.001

-16.14 ± 11.29

-3.00

0.011

4.82 ± 11.29

0.90

0.381

Superior Temporal Gyrus

-79.35 ± 29.94

-5.55

<0.001

-40.30 ± 24.20

-3.50

0.004

42.86 ± 27.16

3.32

0.004

Anterior Cingulate

-15.49 ± 5.14

-6.30

<0.001

-8.87 ± 8.08

-2.31

0.033

5.83 ± 9.04

1.36

0.192

Calcarine Cortex

-3.70 ± 1.80

-4.41

<0.001

-0.43 ± 2.35

-0.39

0.703

3.11 ± -2.18

2.99

0.011

Right Hemisphere

         

Middle Frontal Gyrus

-8.30 ± 3.70

-4.70

<0.001

-4.97 ± 3.26

-3.20

0.007

3.92 ± 4.52

1.82

0.085

Gyrus Rectus

-29.36 ± 12.97

-4.74

<0.001

-3.99 ± 21.89

-0.38

0.706

24.03 ± 20.51

2.46

0.036

Paracentral Lobule

-34.50 ± 14.91

-4.84

<0.001

-18.34 ± 21.67

-1.78

0.092

17.40 ± -16.53

2.21

0.060

Precuneus

-6.89 ± 2.61

-5.53

<0.001

-5.61 ± 5.84

-2.02

0.089

0.80 ± 6.17

0.27

0.788

Hippocampus

-11.41 ± 3.63

-6.58

<0.001

-7.89 ± 5.71

-2.91

0.014

3.01 ± 5.11

1.24

0.232

Anterior Cingulate

-11.20 ± 4.88

-4.80

<0.001

-4.99 ± 5.74

-1.82

0.100

5.42 ± 6.53

1.74

0.100

  1. Units are mm3; Mean ∆: mean difference ± 95% confidence interval.