TY - JOUR AU - Golding, Paul Henry PY - 2014 DA - 2014/09/23 TI - Severe experimental folate deficiency in a human subject – a longitudinal study of biochemical and haematological responses as megaloblastic anaemia develops JO - SpringerPlus SP - 442 VL - 3 IS - 1 AB - The currently accepted theory, that the human liver store of folate is limited to about four months, is based on the findings of Victor Herbert and others of the era before folate fortification of food. A recent model, developed by Lin et al., predicts far greater liver folate storage capacity than reported by Herbert. The conflict between Herbert’s and Lin’s models needs to be resolved experimentally, however current research is restricted because ethical considerations prevent such risky experimentation on patients or healthy human volunteers. The objective was to provide a detailed record of the biochemical and haematological responses to the development of severe experimental folate deficiency in an initially replete human subject. SN - 2193-1801 UR - https://doi.org/10.1186/2193-1801-3-442 DO - 10.1186/2193-1801-3-442 ID - Golding2014 ER -