Figure 4

Role of ROS and attenuated and enhanced NEAPP-AM sensitivity with NAC and BSO. A, B: Influence of intracellular ROS modulation by NAC and BSO on NEAPP-AM-induced cell death. A: TOV21G cells were pretreated with NAC (4 mM) (A) or BSO (2 mM) (B) for 1 hr and then exposed to NEAPP-AM with NAC or BSO for an additional 24 hrs. The cell viability assay was used for evaluation. Each column represents the mean and the bars are SD. Data are representative of at least three independent experiments. *P < 0.05, **P < 0.01 versus control without NAC treatment.