Table 4 Descriptive statistics of PK parameters for netupitant and palonosetron
Netupitant | AUC0-t(h ∗ μg/L) Geo. Mean (Geo. SD) | Cmax(μg/L) Geo. Mean (Geo. SD) | tmax(h) Geo. Mean (Geo. SD) |
|---|---|---|---|
NEPA200/0.5 | |||
 Parent | 4079 (1.712) | 218.7 (1.833) | 5.218 (1.589) |
 M1 | 832.5 (1.719) | 23.55 (1.594) | 14.54 (1.668) |
 M2 | 827.3 (1.722) | 96.94 (1.842) | 3.580 (1.342) |
 M3 | 1348 (1.642) | 46.73 (1.559) | 10.70 (1.490) |
NEPA600/1.5 | |||
 Parent | 12213 (1.925) | 647.7 (2.205) | 6.104 (1.474) |
 M1 | 2007 (1.766) | 53.71 (1.763) | 17.82 (1.948) |
 M2 | 2155 (1.908) | 227.8 (2.024) | 4.131 (1.208) |
 M3 | 2981 (1.707) | 101.5 (1.822) | 11.51 (1.555) |
Palonosetron | AUC 0-t (h ∗ ng/L) Geo. Mean (Geo. SD) | C max (ng/L) Geo. Mean (Geo. SD) | t max (h) Geo. Mean (Geo. SD) |
NEPA200/0.5 | |||
 Parent | 22641 (1.241) | 821.6 (1.277) | 5.464 (1.437) |
 M4 | 541.7 (2.916) | 72.72 (1.379) | 3.675 (1.764) |
 M9 | 416.2 (2.158) | 105.0 (1.383) | 1.746 (1.348) |
NEPA600/1.5 | |||
 Parent | 67918 (1.210) | 2588 (1.239) | 4.229 (1.693) |
 M4 | 5571 (1.348) | 231.0 (1.330) | 3.388 (1.734) |
 M9 | 3973 (1.468) | 348.9 (1.313) | 1.781 (1.535) |