Table 1 Gene expression in Retinoblastoma tumors versus fetal retina
Part | Gene symbol | Probe ID | Fold change | P-value* |
|---|---|---|---|---|
Core complex | FANCA | 203805_PM_s_at | 2.20 | 6.06E-03 |
FANCA | 203806_PM_s_at | 3.54 | 2.32E-06 | |
FANCA | 236976_PM_at | 4.00 | 2.68E-06 | |
FANCC | 242654_PM_at | 1.48 | 3.25E-03 | |
FANCC | 205189_PM_s_at | 1.49 | 2.77E-02 | |
FANCC | 1559513_PM_a_at | 1.52 | 6.28E-03 | |
FANCE | 220255_PM_at | 1.93 | 2.07E-02 | |
FANCF | 218689_PM_at | -1.81 | 1.30E-04 | |
FANCF | 222713_PM_s_at | -1.37 | 2.65E-02 | |
FANCG | 203564_PM_at | 4.00 | 1.52E-07 | |
FANCL | 218397_PM_at | 2.65 | 4.95E-09 | |
FANCM | 234733_PM_s_at | 1.51 | 2.08E-02 | |
FANCM | 242711_PM_x_at | 1.56 | 2.27E-02 | |
Central players | FANCD2 | 242560_PM_at | 1.95 | 4.68E-03 |
FANCI | 223785_PM_at | 1.69 | 2.47E-02 | |
FANCI | 213008_PM_at | 2.55 | 3.08E-03 | |
FANCI | 213007_PM_at | 2.69 | 1.55E-03 | |
Downstrem branch | BRCA2 | 214727_PM_at | 2.31 | 5.87E-03 |
BRCA2 | 208368_PM_s_at | 2.90 | 4.65E-04 | |
PALB2 | 219530_PM_at | 2.18 | 8.70E-09 | |
BRCA1 | 204531_PM_s_at | 2.05 | 2.13E-04 | |
Acitvating E2Fs | E2F1 | 204947_PM_at | 1.61 | 5.47E-03 |
E2F1 | 2028_PM_s_at | 1.86 | 2.56E-03 | |
E2F2 | 228361_PM_at | 2.84 | 2.31E-04 | |
E2F3 | 203692_PM_s_at | 3.50 | 1.94E-08 | |
E2F3 | 203693_PM_s_at | 3.72 | 2.18E-10 | |
Control | CCNE2 | 211814_PM_s_at | 7.77 | 3.13E-10 |
CCNE2 | 205034_PM_at | 8.88 | 1.22E-11 |