Figure 3

FANCA and BRCA1 are coexpressed in Retinoblastoma tumors. Correlation of normalized intensities of the most significant probe sets of FANCA (x-axis: 203806_PM_s_at, P = 2.32E-06) and BRCA1 (y-axis: 204531_PM_s_at, P = 2.13E-04) demonstrates a strong correlation (Pearson = 0.72). Retinoblastoma with no RB1 mutations but with high MYCN amplification (orange/red dots) have relatively low expression of FANCA and BRCA1. Dot sizes indicate levels of E2F3 expression. Retinoblastoma linked to RB1; blue dots: RB1 mutation determined in tumor; grey dots: RB1 mutation not determined in tumor. FR = Fetal Retina.