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Table 1 Differential diagnoses to consider when the double bubble sign is seen on antenatal ultrasound

From: Antenatally detected cystic biliary atresia: differential diagnoses of a double bubble

Site of pathology

Differential diagnoses

Luminal obstruction

Duodenal atresia

Duodenal stenosis

Jejunal atresia

Extra-luminal obstruction

Intestinal malrotation

Annular pancreas

Diaphragmatic hernia

Hepatobiliary

Cystic choledochal malformation

Developmental hepatic cyst

Cystic biliary atresia

Other GI

Duplication cyst

Non-gastrointestinal

Omental cyst, ovarian cyst, renal cyst

Non-pathological

Transient bubble associated with slow peristalsis