Figure 6From: Overstimulation can create health problems due to increases in PI3K/Akt/GSK3 insensitivity and GSK3 activityPotential pathways tested or stated in the study lead to diseases including AMD. Details of the pathways are depicted in the text. sFRP2 (RM): recombinant mouse sFRP2. Red arrows and blocks: provided that the stimuli are overstimulation of PI3K/Akt, which is the improvement of the doctrine. The numbers 1, 2, 3 in the block lines represent insensitivity stages 1(GSK3 insensitivity), 2 (Akt insensitivity), 3 (PI3K insensitivity). PI3K/pSAkt/pSGSK3 is put into the red frame. The black arrows between VEGF and PI3K, and stimuli and receptors indicate stimulation without causing insensitivity or high GSK3 activity.Back to article page