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Table 2 Biology

From: Bone marrow fibrosis as a feature of systemic lupus erythematosus: a case report and literature review

Nref Age yrs M/F Hb g/dl Pl 109/l WBC 109/l N 109/l L 109/l ANA DNA other Co test LC Bone marrow examination
1 (Sarkar et al.2009) 45 M 5.3 25 2.5 1.2 1 1/640 +   +   Hypercellular marrow with focal lymphocytic infiltration.
2 (Sacre et al.2009) 44 F 7 65     high +   -   Hypercellularity with marked reticulin fibrosis.
3 (Pillai et al.2009) 40 F 10.6 25   0   1/320 -   + + Hypercellular with increased megakaryocytes and reticulin (grade 3).
4 (Aziz et al.2004) 22 F 6.2 18 1.2    1/160     + Hypercellularity with an increased number of megakaryocytes. Silver stain showed increased reticulin fibrosis and the presence of patchy areas of collagenized marrow.
5 (Kiss et al.2000) 18 F 4.2 28 0.9    high   aCL    Significant increase in the amount of reticulin fibres (40%, Beumaister 3–4), hypocellularity of the myeloid components and massive lymphocytic infiltration.
6 (Durupt et al.2000) 29 F 9.4 102 1.1 0.6 0.3 1/1120 +    + All normal hematopoietic elements with a small increase in mature megakaryocytes and marked inflammatory medullar reaction with plasmocytosis, systematized increase in reticulin (grade 1).
7 (Vora et al.1998) 22 F 9 60 4    1/1000 -     Marked osteomyelosclerosis with severe fibrosis of the marrow spaces and near-total effacement of normal hematopoiesis.
8 (Aharon et al.1997; Amital et al.2003) 54 F 5.1 96 3.1 2.2 0.6 high + aCL, anti-histone, anti-SSA   + Focal hypercellularity, many reticulin and collagen fibers, normal appearance of the red cell and white cell lines, mild megakaryocytosis with few mildly abnormal megakaryocytes.
9 (Agarwal et al.1995) 12 F 9.6 4 4.7 0.7 3.3 1/40 -   -   Extremely hypocellular marrow with residual patches of hematopoietic cells. Reticulin stain showed a marked increase in fine fibrosis, which was diffuse grade 3.
10 (Ramakrishna et al.1995) 18 F 5.4 30 6    1/2560 + LA, aCL, antiplatelet + + Markedly hypercellular marrow with erythroid hyperplasia, plentiful megakaryocytes and markedly increased reticulin.
11 (Paquette et al.1994) 68 M 5.7 222 3.5    1/5280 -    + Hypercellular, increased stroma and reticulin fibrosis.
12 (Paquette et al.1994) 27 F 5 1 5.9    1/80 -   + - Fibrosis with megakaryocyte clustering.
13 (Paquette et al.1994) 23 F 9.5 55 4.2    high     - Fibrosis, open sinusoids, megakaryocyte clusters.
14 (Paquette et al.1994) 56 F 9.7 76 5.4    high +   - + Erythroid hyperplasia, increased megakaryocytes, fibroblast proliferation, reticulin fibrosis.
15 (Paquette et al.1994) 18 F 2.7 4 7.7    high +   + + Bone marrow fibrosis, hypercellular marrow, increased megakaryocytes with clustering.
16 (Paquette et al.1994) 70 F 4.2 20 3.8    high -   + + Advanced bone marrow fibrosis, hypocellular marrow, predominance of megakaryocytes.
17 (Paquette et al.1994) 62 F 9.3 35 3    high -    + Advanced bone marrow fibrosis, marked osteosclerosis.
18 (Paquette et al.1994) 69 F 6.8 39 6.8    high -    - Hypercellular with increased, clustering megakaryocytes; stroma moderately increased by accumulation of fibrillar reticulin.
19 (Hirose et al.1993) 54 F 6.9 17 1.7    1/320 - aCL, LA   + Marked marrow fibrosis with reduced numbers of erythroid precursors and normal proliferation of both megakaryocytes and myeloid series, the reticulin content was increased.
20 (Borba et al.1993) 39 F 9.7 341 2.4 0.9   1/200 - anti-neutrophil + + All normal hematopoeitic elements with localised fibrosis, reticulin was moderately increased.
21 (Foley-Nolan et al.1992) 20 F 10.5 45 4.5 1.3 1.9 1/800    + + Hypercellular with a marked increase in the number of megakaryocytes and a diffuse, significant increase in reticulin content.
22 (Inoue et al.1992) 24 F 6.8 2 3.8    1/100 - antiplatelet - + Bone marrow fibrosis characterized by marked hyperplasic marrow with an increase in reticulin fibers, all elements including megakaryocytes increased in number.
23 (Matsouka et al.1989) 60 F   20 4 1.4 1.4 1/320    - - Presence of dense fibrous tissue with fibroblasts, paucity of immature and polymorphonuclear cells.
24 (el Mouzan et al.1988) 13 F 6.5 10 1.3 0.2 1 1/640 + rhumatoid factor + + Decreased bone marrow activity with 1:1 myeloid to erythroid ratio, megakaryocytes quantitatively normal, increased reticulo-endothelial activity and fibrosis.
25 (Kaelin and Spivak1986) 27 F 13.1 5 4.4 2.8 0.9 1/1280 + antiplatelet, anti-neutrophil + + Contained all normal hematopoietic elements with a slight increase in mature megakaryocytes, markedly increased reticulin.
26 (Nanji and Jetha1984) 28 M 8.4 1 0.3    high    -   Hypocellular in some areas and hypercellular in others, megakaryocytes decreased in number, increased numbers of histiocytes and fibroblasts, extensive fibrosis and diffuse increased in reticulin.
27 (Daly and Scott1983) 16 F 7 28 1.7 0.5   1/1280 +   - + Marked marrow fibrosis with reduced numbers of erythroid precursors, plentiful megakaryocytes, greatly increased reticulin content.
Present 29 F 2.9 15 0.48 0.28 0.08 1/1280 + anti-SSA, RNP 70, U1-RNP - + Hypercellular marrow (cellularity : 80%) with focal lymphocytic infiltration, dysmyelopoiesis, erythrophagocytosis and grade 1–2 fibrosis.
  1. Hb: hemoglobin, Pl: platelets, WBC: white blood count, N: neutrophils, L: lymphocytes, ANA: anti-nuclear antibodies, DNA: anti double-stranded DNA antibodies, Co test: Coombs test, LC: low complement, LA: lupus anticoagulant, aCL: anticardiolipin.