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Table 2 Summary of six trials considered for simulation with β = 0.10 and a one-sided α = 0.025

From: Interim analysis for binary outcome trials with a long fixed follow-up time and repeated outcome assessments at pre-specified times

Standard group event proportion (π0) Experimental group event proportion (π1) Absolute risk reduction (π0-π1) N
0.30 0.25 0.05 3342
0.30 0.20 0.10 796
0.30 0.10 0.20 160
0.50 0.45 0.05 4182
0.50 0.40 0.10 1030
0.50 0.30 0.20 242