Table 1 Cell cycle analysis of K-562 tumor cell lines after treatment with cis -tetraammine(oxalato)ruthenium(III) dithionate
Control | Ru 1.5 μM | Ru 10 μM | Ru 40 μM | Ru 150 μM | |
|---|---|---|---|---|---|
24 h | Mean ± S.D. | Mean ± S.D | Mean ± S.D | Mean ± S.D | Mean ± S.D |
Sub-G0/G1 | 14.45 ± 0.6 | 30.20 ± 2.1 | 31.20 ± 1.4 | 59.00 ± 2.3 | 68.90 ± 1.8 |
G1 | 27.20 ± 0.3 | 25.25 ± 2.1 | 19.55 ± 0.9 | 11.50 ± 1.7 | 14.75 ± 0.9 |
S | 19.05 ± 0.1 | 27.50 ± 1.1 | 29.10 ± 1.1 | 18.60 ± 2.1 | 11.40 ± 0.8 |
G2 | 14.10 ± 0.1 | 14.85 ± 0.8 | 18.10 ± 0.7 | 9.15 ± 1.6 | 4.00 ± 0.1 |
48 h | |||||
Sub-G0/G1 | 10.70 ± 0.7 | 24.65 ± 1.1 | 40.55 ± 2.6 | 68.60 ± 1.1 | 67.60 ± 0.1 |
G1 | 35.65 ± 0.6 | 31.70 ± 1.0 | 14.85 ± 2.6 | 8.35 ± 0.4 | 19.30 ± 0.4 |
S | 21.35 ± 0.4 | 30.05 ± 0.8 | 26.35 ± 2.1 | 14.35 ± 0.9 | 9.75 ± 0.2 |
G2 | 10.00 ± 1.4 | 12.50 ± 0.3 | 17.05 ± 2.3 | 7.85 ± 0.1 | 2.95 ± 0.1 |
72 h | |||||
Sub-G0/G1 | 15.50 ± 16.0 | 34.50 ± 1.4 | 45.95 ± 1.1 | 84.70 ± 0.3 | 70.50 ± 2.8 |
G1 | 35.45 ± 10.1 | 31.75 ± 0.5 | 17.05 ± 0.2 | 4.95 ± 0.1 | 18.70 ± 1.0 |
S | 20.05 ± 4.7 | 23.80 ± 0.6 | 26.05 ± 0.6 | 7.20 ± 0.6 | 9.25 ± 1.6 |
G2 | 7.45 ± 0.8 | 9.30 ± 0.4 | 10.50 ± 0.3 | 3.10 ± 0.1 | 1.45 ± 0.2 |