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Figure 2

From: Pcf1, a large subunit of CAF-1, required for maintenance of checkpoint kinase Cds1 activity

Figure 2

Disturbance of the activation of the DNA replication checkpoint by deletion of pcf1+. (A) Mobility of Cds1 prepared from wild type and Δpcf1 mutant on SDS-PAGE at various times after HU treatment. (B) Time course of septum formation in cells (septation index) in Δpcf1 mutant (closed square) and wild type cells (open circle) after HU treatment. (C) DAPI-stained cells of wild type and Δpcf1 mutant 6 h after HU treatment. Arrowheads indicate cells with a segregated nucleus. (D) Incidence of cells with a segregated nucleus 6 h after HU treatment.

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