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Table 2 Multivariable analysis of KLK2 SNPs and hK2 levels in predicting the presence of prostate cancer at the time of repeat biopsy

From: Human kallikrein-2 gene and protein expression predicts prostate cancer at repeat biopsy

Subgroup   Odds Ratio 95% CI P
Age   1.35 1.02 - 1.79 0.049
PSA (ng/mL)   1.41 1.02 - 1.96 0.092
DRE   1.20 0.80 - 1.80 0.372
Presence of LUTS   0.80 0.56 – 1.13 0.205
TRUS volume (cc)   0.33 0.24 - 0.45 < 0.0001
Family history   1.40 0.86 - 2.28 0.175
Ethnic background Other + Asian 1.00   0.006
White 2.30 1.15 - 4.62
Black 4.01 1.70 - 9.45
Initial Biopsy Pathology BPH or Normal 1.00   
HGPIN 1.79 1.22 - 2.62 0.0002
ASAP 2.62 1.51 - 4.54
rs2664155 (KL1) GG vs. GA 1.47 0.84 - 2.57 0.218
GG vs. AA 1.14 0.78 - 1.69
rs198977 (KL2) TT vs. CT 1.23 0.72 – 2.09 0.049
TT vs. CC 1.81 1.04 – 3.13
hK2 Level (ng/mL)   2.03 1.4 – 2.99 0.002