In vivo interactions of continuous flucloxacillin infusion and high-dose oral rifampicin in the serum of 15 patients with bone and soft tissue infections due to Staphylococcus aureus - a methodological and pilot study

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Table 1 Reciprocal serum minimal inhibitory and bactericidal dilutions ⁺

	Reciprocal serum minimal inhibitory dilutions (reciprocal titer)⁺				Reciprocal serum minimal bacterial dilutions (reciprocal titer)⁺
	FOXA alone	FOXA and RIF			FOXA alone	FOXA and RIF
				Activity change after RIF combination (*)				Activity change after RIF combination (*)
Patient	TP-A	TP-B	TP-C		TP-A	TP-B	TP-C
1	32	128	256	2.5	8	<2	<2	-3
2	256	64	256	-1	<2	4	<2	1
3	32	64	1024	3	<2	<2	1024	9
4	128	1024	1024	3	<2	32	32	5
5	128	128	128	0	<2	<2	16	2
6	512	64	128	-2.5	<2	<2	<2	0
7	32	128	32	1	4	<2	<2	-2
8	128	512	512	2	2	<2	<2	-1
9	64	256	512	2.5	64	<2	<2	-6
10	32	128	256	2.5	8	<2	<2	-3
11	128	512	1024	2.5	128	512	1024	2.5
12	64	512	128	2	4	<2	<2	-2
13	128	512	512	2	2	<2	2	-0.5
14	32	128	128	2	16	<2	<2	-4
15	256	128	256	-0.5	64	<2	<2	-6

FOXA = Continuous intravenous flucloxacillin 12 g/d. RIF = Oral rifampin 600 mg bid.
⁺Units are not written to spare space. Units are in μg/ml.
*Activity change expressed in dilutions. Calculated as difference between activity with FOXA alone (time point A) and the mean activity in the 2 conditions measured after RIF adjunction (time points B and C). Positive values denote increase activity, negative ones decreased activity.