Skip to main content

Table 1 Reciprocal serum minimal inhibitory and bactericidal dilutions +

From: In vivo interactions of continuous flucloxacillin infusion and high-dose oral rifampicin in the serum of 15 patients with bone and soft tissue infections due to Staphylococcus aureus - a methodological and pilot study

  Reciprocal serum minimal inhibitory dilutions (reciprocal titer)+ Reciprocal serum minimal bacterial dilutions (reciprocal titer)+
FOXA alone FOXA and RIF    FOXA alone FOXA and RIF   
    Activity change after RIF combination (*)     Activity change after RIF combination (*)
Patient TP-A TP-B TP-C   TP-A TP-B TP-C  
1 32 128 256 2.5 8 <2 <2 -3
2 256 64 256 -1 <2 4 <2 1
3 32 64 1024 3 <2 <2 1024 9
4 128 1024 1024 3 <2 32 32 5
5 128 128 128 0 <2 <2 16 2
6 512 64 128 -2.5 <2 <2 <2 0
7 32 128 32 1 4 <2 <2 -2
8 128 512 512 2 2 <2 <2 -1
9 64 256 512 2.5 64 <2 <2 -6
10 32 128 256 2.5 8 <2 <2 -3
11 128 512 1024 2.5 128 512 1024 2.5
12 64 512 128 2 4 <2 <2 -2
13 128 512 512 2 2 <2 2 -0.5
14 32 128 128 2 16 <2 <2 -4
15 256 128 256 -0.5 64 <2 <2 -6
  1. FOXA = Continuous intravenous flucloxacillin 12 g/d. RIF = Oral rifampin 600 mg bid.
  2. +Units are not written to spare space. Units are in μg/ml.
  3. *Activity change expressed in dilutions. Calculated as difference between activity with FOXA alone (time point A) and the mean activity in the 2 conditions measured after RIF adjunction (time points B and C). Positive values denote increase activity, negative ones decreased activity.