Figure 1

Effects of pentoxifylline (PTX) treatments (100, 50 and 25 mg/kg, p.o.) on glycemia and triglyceride (TG) levels in diabetic rats. Glibenclamide (GLI, 5 mg/kg, p.o.) was used as reference. The values are means ± SEM from 6–18 animals per group. A and B, after 1 week treatment, and C and D after longer treatments (1 week to 3-months) with PTX (50 mg/kg). A (Glycemia), PTX100: ***p < 0.0002; PTX50: ***p < 0.0001; PTX25: *p < 0.0102; GLI5: **p < 0.0014. B (TG), PTX100: **p < 0.0013; PTX50: ***p < 0.0003; PTX25: **p < 0.0082; GLI5: ***p < 0.0004. C (Glycemia) - PTX50, 1 week: ***q = 42.27; 2 weeks: ***q = 18.78; 1 month: ***q = 31.82; 2 months: ***q = 26.31’; 3 months: ***q = 29.63. D (TG) - PTX50, 1 week: ***q = 13.42; 2 weeks: ***q = 18.18;1 month: ***q = 14.75; 2 months: ***q = 12.44; 3 months: ***q = 20.23. Data analyzed by One-way ANOVA, followed by Newman-Keuls as the post hoc test or paired Student t test. All comparisons were done after (A) vs. before (B) treatments, in each group. DC = untreated diabetic controls.