High phosphoserine in sepsis: panel of clinical and plasma amino acid correlations

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Table 2 Plasma phosphoserine correlates

	Phosphoserine ≤ 12	Phosphoserine > 12
Phosphoserine	10 (7–12)	15 (13–27)
Cystathionine	3 (1–13)	6 (1–27)
3-methylhistidine	3 (1–7)	10 (2–29)
Histidine	69.5 (50.5-97)	80 (54–409)
Hydroxyproline	10 (5–22)	14 (6–57)
Tyrosine	54 (36–91)	59 (40–166)
SOFA score	6 (3–10)	10 (3–15)
p < 0.001 for all differences
Regression equation:
3-methylhistidine = 4.32 + 0.45 (phosphoserine) +0.03 (creatinine) –3.92(AA dose)
multiple r = 0.80; partial r for AA dose = − 0.44; p < 0.001 for each coefficient and for whole regression

Upper part. Medians and 5^th - 95^th percentiles for the best AA correlates of phosphoserine (micromol/L for all) and SOFA score, for measurements with phosphoserine > 12 (median value) compared to measurements with phosphoserine ≤ 12. Lower part. Regression equation assessing the relationship between plasma 3-methylhistidine, phosphoserine, creatinine (micromol/L for all) and nutritional AA dose (g/kg/day). Median creatinine 70.72; 5^th - 95^th percentiles 35.36 - 238.68.