Figure 3From: DLC1 suppresses NF-κB activity in prostate cancer cells due to its stabilizing effect on adherens junctionsSuppression of NF-κB activity is GAP- and α –catenin-dependent (A) Western blot of pNF-κB (p65), NF-κB (p65) and DLC1 (V-5) expression in C4-2-B2 cells transduced with Ad-Lac Z or Ad-DLC1 and stably transfected with either DLC1 GAP-mutated (R718E) or α -catenin binding deficient constructs (Δ340-435). (B) Dual Luciferase reporter assay for NF-κB activity in above-mentioned C4-2-B2 cells. All values are means ± SD of three independent counts.Back to article page