Pre- and postoperative alcohol consumption in breast cancer patients: impact on early events

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Table 3 Pre- and postoperative alcohol consumption in relation to risk for early breast cancer events (significant associations are indicated in bold)

		Risk for early breast cancer events
			All		Lymph node negative^c				Lymph node positive^c
Alcohol consumption	No.	No. of events	Crude HR	Adj. HR^a	No.	No. of events	Crude HR	Adj. HR^b	No.	No. of events	Crude HR	Adj. HR^b
			(95% CI)	(95% CI)			(95% CI)	(95% CI)			(95% CI)	(95% CI)
Preoperative	934	100			572	49			360	50
None	300	39	Ref.	Ref.	188	14	Ref.	Ref.	110	24	Ref.	Ref.
Any (1+ drinks/week)	634	61	0.66 (0.44-0.99)	0.69 (0.45-1.04)	384	35	1.16 (0.62-2.15)	1.32 (0.69-2.52)	250	26	0.40 (0.23-0.70)	0.42 (0.23-0.75)
0 drinks/week	300	39	Ref.	Ref.	188	14	Ref.	Ref.	110	24	Ref.	Ref.
1-3 drinks/week	369	28	0.51 (0.31-0.83)	0.55 (0.34-0.91)	227	15	0.79 (0.38-1.63)	0.99 (0.47-2.10)	142	13	0.36 (0.18-0.71)	0.37 (0.18-0.74)
4-9 drinks/week	232	30	0.94 (0.58-1.51)	0.90 (0.55-1.48)	134	18	1.93 (0.96-3.90)	1.89 (0.90-3.96)	98	12	0.47 (0.23-0.94)	0.51 (0.25-1.04)
10+ drinks/week	33	3	0.59 (0.18-1.92)	0.70 (0.21-2.32)	23	2	1.13 (0.26-4.98)	1.35 (0.30-6.15)	10	1	0.31 (0.04-2.32)	0.31 (0.04-2.36)

^aAdjusted for age at diagnosis (linear), invasive tumor size (<21 mm versus ≥21 mm or skin or muscular involvement independent of size), axillary lymph node involvement (yes/no), tumor grade III (yes/no), ER status (+/−), BMI (<25.0 kg/m2), preoperative current smoking, and treatment; tamoxifen, aromatase inhibitors, chemotherapy, and radiation therapy (missing data for 26 patients and 0 patients, respectively).
^bAdjusted for age at diagnosis, invasive tumor size, tumor grade, ER status, BMI, preoperative current smoking, and treatment; tamoxifen, aromatase inhibitors, chemotherapy, and radiation therapy.
^cMissing data on lymph node status for 2 patients.