Table 2 Cohort characteristics, adverse event frequencies and costs
1st Line Taxane | 1st Line Capecitabine | 2nd Line Taxane | 2nd Line Capecitabine | |
|---|---|---|---|---|
Number of patients | 7934 | 634 | 6339 | 360 |
Age, mean (years) | 49.3 | 51.8 | 48.4 | 50.1 |
Days per treatment episode, mean (SD)‡ | ||||
With no adverse events | 128 (110)** | 150 (123)** | 91 (71)** | 118 (95)** |
With any adverse event | 167 (134) | 231 (209) | 101 (98) | 183 (156) |
Adverse events, n (%) | ||||
Any adverse event† | 6647 (83.8) | 286 (45.1)** | 4313 (68.0) | 152 (42.2)** |
Liver enzymes increased | 5 (0.1) | 0 (0.0) | 1 (0.0) | 0 (0.0) |
Anemia | 1627 (20.5) | 82 (12.9) | 1017 (16.0) | 49 (13.6) |
Arthralgia | 606 (7.6) | 78 (12.3) | 367 (5.8) | 23 (6.4) |
Bilirubin elevated | 2 (0.0) | 0 (0.0) | 2 (0.0) | 0 (0.0) |
Constipation | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Diarrhea | 500 (5.0) | 25 (3.9) | 124 (1.9) | 9 (2.5) |
Dyspnea | 733 (9.2) | 62 (9.8) | 394 (6.2) | 27 (7.5) |
Edema | 331 (4.2) | 21 (3.3) | 199 (3.1) | 3 (0.8) |
Fatigue | 817 (10.3) | 43 (6.8) | 493 (7.8) | 26 (7.2) |
Infection | 750 (9.4) | 39 (6.1) | 354 (5.6) | 29 (8.1) |
Injection site reactions | 4 (0.1) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Leukopenia | 40 (0.5) | 0 (0.0) | 29 (0.5) | 1 (0.3) |
Myalgia | 171 (2.2) | 8 (1.3) | 105 (1.6) | 3 (0.8) |
Nausea/vomiting | 206 (2.6) | 13 (2.0) | 113 (1.8) | 12 (3.3) |
Neutropenia | 203 (2.6) | 2 (0.3) | 12 (0.2) | 0 (0.0) |
Peripheral neuropathy | 195 (2.5) | 18 (2.8) | 261 (4.1) | 10 (2.8) |
Pharyngitis | 181 (2.3) | 10 (1.6) | 100 (1.6) | 5 (1.4) |
Pyrexia | 929 (11.7) | 27 (4.3) | 247 (3.9) | 14 (3.9) |
Rash | 312 (3.9) | 17 (2.7) | 161 (2.5) | 7 (1.9) |
Stomatitis | 101 (1.3) | 2 (0.3) | 32 (0.5) | 2 (0.6) |
Thrombocytopenia | 64 (0.8) | 3 (0.5) | 6 (0.1) | 0 (0.0) |
Unadjusted monthly costs, mean (SD) † | ||||
Chemotherapy costs | $6,256 (4659) | $3,761 (3221)** | $3,062 (4096) | $4,344 (3380)** |
Other medication costs | $312 (794) | $279 (651) | $268 (873) | $281 (560) |
Hospitalization costs | $817 (4084) | $1,065 (6159) | $490 (2826) | $1,655 (7324)* |
Emergency department costs | $90 (696) | $46 (180)** | $99 (691) | $68 (312)* |
Outpatient services costs | $293 (2607) | $1,220 (4465)** | $7,021 (5720) | $4,032 (6826)** |
Total costs | $7,770 (6880) | $6,372 (8313)** | $10,939 (8145) | $10,381 (11139) |