|
Biomarker (Quartiles or tertiles)
|
Odds ratio (Unadjusted)
|
Odds ratio (Adjusted for Hypertension and baseline eGFR)
|
P-trend
|
|---|
|
C-Reactive Protein
| | | |
|
<1.62 mg/dL
|
Ref
|
Ref
|
0.73
|
|
1.62-3.31
|
1.18 (0.44-3.07)
|
0.95 (0.34-2.60)
|
|
3.31-7.68
|
1.35 (0.53-3.48)
|
1.21 (0.45-3.24)
|
|
>7.68
|
0.78 (0.28-2.17)
|
0.74 (0.25-2.13)
|
|
TNF-α
| | | |
|
<4.26 pg/mL
|
Ref
|
Ref
|
0.23
|
|
4.26-5.71
|
0.82 (0.28-2.45)
|
0.74 (0.24-2.26)
|
|
5.71-8.09
|
1.13 (0.40-3.18)
|
0.95 (0.32-2.79)
|
|
>8.09
|
2.73 (1.06-7.06)
|
1.68 (0.60-4.71)
|
|
IL-6
| | | |
|
<2.41 pg/mL
|
Ref
|
Ref
|
0.50
|
|
2.41-3.56
|
1.84 (0.66-5.11)
|
1.60 (0.55-4.65)
|
|
3.56-5.92
|
1.35 (0.46-3.93)
|
1.11 (0.36-3.40)
|
|
>5.92
|
2.20 (0.80-6.07)
|
1.58 (0.58-4.82)
|
|
E-selectin
| | | |
|
<35.05 ng/mL
|
Ref
|
Ref
|
0.045
|
|
35.05-47.09
|
3.17 (1.04-9.63)
|
2.70 (0.86-8.46)
|
|
47.09-62.48
|
2.05 (0.64-6.56)
|
1.74 (0.52-5.76)
|
|
>62.48
|
3.68 (1.22-11.12)
|
4.01 (1.27-12.69)
|
|
VCAM
| | | |
|
<1011.85 ng/mL
|
Ref
|
Ref
|
0.73
|
|
1011.85-1172.06
|
1.16 (0.43-3.14)
|
1.31 (0.46-3.77)
|
|
1172.06-1352.13
|
1.05 (0.38-2.89)
|
0.83 (0.29-2.40)
|
|
>1352.13
|
1.55 (0.60-3.99)
|
1.29 (0.46-3.58)
|
|
ICAM
| | | |
|
≤122.38 ng/mL
|
Ref
|
Ref
|
0.97
|
|
122.39 = 150-.76
|
0.55 (0.21-1.49)
|
0.62 (0.22-1.73)
|
|
150.77-192.26
|
0.72 (0.28-1.85)
|
0.70 (0.26-1.89)
|
|
>192.26
|
0.85 (0.34-2.15)
|
0.96 (0.37-2.54)
|
|
ACR
| | | |
|
<30 mg/g
|
Ref
|
Ref
|
<0.001
|
|
30–300
|
2.60 (1.14-5.96)
|
2.13 (0.90-5.02)
|
|
>300
|
12.73 (4.19-38.66)
|
9.70 (2.81-33.52)
| |
- Multivariable model adjusted for history of hypertension and estimated glomerular filtration rate (eGFR). Test of trend applied to adjusted model.
