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Table 4 Associations between baseline biomarkers and acute kidney injury (AKI) after hospitalization for sepsis

From: Association of inflammatory and endothelial cell activation biomarkers with acute kidney injury after sepsis

Biomarker (Quartiles or tertiles) Odds ratio (Unadjusted) Odds ratio (Adjusted for Hypertension and baseline eGFR) P-trend
C-Reactive Protein    
 <1.62 mg/dL Ref Ref 0.73
 1.62-3.31 1.18 (0.44-3.07) 0.95 (0.34-2.60)
 3.31-7.68 1.35 (0.53-3.48) 1.21 (0.45-3.24)
 >7.68 0.78 (0.28-2.17) 0.74 (0.25-2.13)
TNF-α    
 <4.26 pg/mL Ref Ref 0.23
 4.26-5.71 0.82 (0.28-2.45) 0.74 (0.24-2.26)
 5.71-8.09 1.13 (0.40-3.18) 0.95 (0.32-2.79)
 >8.09 2.73 (1.06-7.06) 1.68 (0.60-4.71)
IL-6    
 <2.41 pg/mL Ref Ref 0.50
 2.41-3.56 1.84 (0.66-5.11) 1.60 (0.55-4.65)
 3.56-5.92 1.35 (0.46-3.93) 1.11 (0.36-3.40)
 >5.92 2.20 (0.80-6.07) 1.58 (0.58-4.82)
E-selectin    
 <35.05 ng/mL Ref Ref 0.045
 35.05-47.09 3.17 (1.04-9.63) 2.70 (0.86-8.46)
 47.09-62.48 2.05 (0.64-6.56) 1.74 (0.52-5.76)
 >62.48 3.68 (1.22-11.12) 4.01 (1.27-12.69)
VCAM    
 <1011.85 ng/mL Ref Ref 0.73
 1011.85-1172.06 1.16 (0.43-3.14) 1.31 (0.46-3.77)
 1172.06-1352.13 1.05 (0.38-2.89) 0.83 (0.29-2.40)
 >1352.13 1.55 (0.60-3.99) 1.29 (0.46-3.58)
ICAM    
 ≤122.38 ng/mL Ref Ref 0.97
 122.39 = 150-.76 0.55 (0.21-1.49) 0.62 (0.22-1.73)
 150.77-192.26 0.72 (0.28-1.85) 0.70 (0.26-1.89)
 >192.26 0.85 (0.34-2.15) 0.96 (0.37-2.54)
ACR    
 <30 mg/g Ref Ref <0.001
 30–300 2.60 (1.14-5.96) 2.13 (0.90-5.02)
 >300 12.73 (4.19-38.66) 9.70 (2.81-33.52)  
  1. Multivariable model adjusted for history of hypertension and estimated glomerular filtration rate (eGFR). Test of trend applied to adjusted model.