Table 4 Associations between baseline biomarkers and acute kidney injury (AKI) after hospitalization for sepsis
Biomarker (Quartiles or tertiles) | Odds ratio (Unadjusted) | Odds ratio (Adjusted for Hypertension and baseline eGFR) | P-trend |
|---|---|---|---|
C-Reactive Protein | |||
<1.62 mg/dL | Ref | Ref | 0.73 |
1.62-3.31 | 1.18 (0.44-3.07) | 0.95 (0.34-2.60) | |
3.31-7.68 | 1.35 (0.53-3.48) | 1.21 (0.45-3.24) | |
>7.68 | 0.78 (0.28-2.17) | 0.74 (0.25-2.13) | |
TNF-α | |||
<4.26 pg/mL | Ref | Ref | 0.23 |
4.26-5.71 | 0.82 (0.28-2.45) | 0.74 (0.24-2.26) | |
5.71-8.09 | 1.13 (0.40-3.18) | 0.95 (0.32-2.79) | |
>8.09 | 2.73 (1.06-7.06) | 1.68 (0.60-4.71) | |
IL-6 | |||
<2.41 pg/mL | Ref | Ref | 0.50 |
2.41-3.56 | 1.84 (0.66-5.11) | 1.60 (0.55-4.65) | |
3.56-5.92 | 1.35 (0.46-3.93) | 1.11 (0.36-3.40) | |
>5.92 | 2.20 (0.80-6.07) | 1.58 (0.58-4.82) | |
E-selectin | |||
<35.05 ng/mL | Ref | Ref | 0.045 |
35.05-47.09 | 3.17 (1.04-9.63) | 2.70 (0.86-8.46) | |
47.09-62.48 | 2.05 (0.64-6.56) | 1.74 (0.52-5.76) | |
>62.48 | 3.68 (1.22-11.12) | 4.01 (1.27-12.69) | |
VCAM | |||
<1011.85 ng/mL | Ref | Ref | 0.73 |
1011.85-1172.06 | 1.16 (0.43-3.14) | 1.31 (0.46-3.77) | |
1172.06-1352.13 | 1.05 (0.38-2.89) | 0.83 (0.29-2.40) | |
>1352.13 | 1.55 (0.60-3.99) | 1.29 (0.46-3.58) | |
ICAM | |||
≤122.38 ng/mL | Ref | Ref | 0.97 |
122.39 = 150-.76 | 0.55 (0.21-1.49) | 0.62 (0.22-1.73) | |
150.77-192.26 | 0.72 (0.28-1.85) | 0.70 (0.26-1.89) | |
>192.26 | 0.85 (0.34-2.15) | 0.96 (0.37-2.54) | |
ACR | |||
<30 mg/g | Ref | Ref | <0.001 |
30–300 | 2.60 (1.14-5.96) | 2.13 (0.90-5.02) | |
>300 | 12.73 (4.19-38.66) | 9.70 (2.81-33.52) |