Table 3 Comparison of variables to determine the power of surrogate markers to the ‘gold-standard’ for UTI diagnosis (bacterial culture), in a cohort of renal transplant recipients
Sensitivity (95% CL) | Specificity (95% CL) | PPV (95% CL) | LR+ | LR- | Accuracy | Youden’s index | DOR (95% CL) | |
|---|---|---|---|---|---|---|---|---|
(1) Leukocyte esterase | 0.500 (0.21-0.79) | 0.024 (0.00-0.13) | 0.130 (0.05-0.26) | 0.513 | 20.5 | 0.132 | −0.476 | 0.025 (0.00-0.25) |
(2) Nitrite | 0.167 (0.02-0.48) | 0.951 (0.83-0.99) | 0.500 (0.07-0.93) | 3.417 | 0.876 | 0.774 | 0.118 | 3.900 (0.49-31.22) |
(3) Combined dipsticks | 0.000 (0.00-0.60) | 0.333 (0.01-0.91) | 0.000 (0.00-0.84) | 0.000 | 3.000 | 0.143 | −0.667 | 0.067 (0.00-2.33) |
(4) Pyuria | 0.750 (0.43-0.95) | 0.146 (0.06-0.29) | 0.205 (0.10-0.35) | 0.879 | 1.708 | 0.283 | −0.104 | 0.514 (0.11-2.47) |
(5) ATP | 0.250 (0.05-0.57) | 1.000 (0.91-1.00) | 1.000 (0.29-1.00) | Infinity | 0.750 | 0.830 | 0.250 | 30.580 (1.45-643.50) |
(6) IB | 0.083 (0.00-0.38) | 0.463 (0.31-0.63) | 0.043 (0.00-0.22) | 0.155 | 1.978 | 0.377 | −0.453 | 0.079 (0.01-0.67) |
(7) Combined ATP and IB | 1.000 (0.03-1.00) | 1.000 (0.81-1.00) | 1.000 (0.03-1.00) | Infinity | 0.000 | 1.000 | 1.000 | 105.000 (1.48-7441.80) |