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Table 3 Comparison of variables to determine the power of surrogate markers to the ‘gold-standard’ for UTI diagnosis (bacterial culture), in a cohort of renal transplant recipients

From: Urinary ATP and visualization of intracellular bacteria: a superior diagnostic marker for recurrent UTI in renal transplant recipients?

  Sensitivity (95% CL) Specificity (95% CL) PPV (95% CL) LR+ LR- Accuracy Youden’s index DOR (95% CL)
(1) Leukocyte esterase 0.500 (0.21-0.79) 0.024 (0.00-0.13) 0.130 (0.05-0.26) 0.513 20.5 0.132 −0.476 0.025 (0.00-0.25)
(2) Nitrite 0.167 (0.02-0.48) 0.951 (0.83-0.99) 0.500 (0.07-0.93) 3.417 0.876 0.774 0.118 3.900 (0.49-31.22)
(3) Combined dipsticks 0.000 (0.00-0.60) 0.333 (0.01-0.91) 0.000 (0.00-0.84) 0.000 3.000 0.143 −0.667 0.067 (0.00-2.33)
(4) Pyuria 0.750 (0.43-0.95) 0.146 (0.06-0.29) 0.205 (0.10-0.35) 0.879 1.708 0.283 −0.104 0.514 (0.11-2.47)
(5) ATP 0.250 (0.05-0.57) 1.000 (0.91-1.00) 1.000 (0.29-1.00) Infinity 0.750 0.830 0.250 30.580 (1.45-643.50)
(6) IB 0.083 (0.00-0.38) 0.463 (0.31-0.63) 0.043 (0.00-0.22) 0.155 1.978 0.377 −0.453 0.079 (0.01-0.67)
(7) Combined ATP and IB 1.000 (0.03-1.00) 1.000 (0.81-1.00) 1.000 (0.03-1.00) Infinity 0.000 1.000 1.000 105.000 (1.48-7441.80)
  1. Key: PPV, positive predictive value; LR+, positive likelihood ratio; LR-, negative likelihood ratio; DOR, diagnostic odds ratio; IB, intracellular bacteria.