FGF21 elevates mitochondrial antioxidants in the dopaminergic neurons. Human dopaminergic neurons were treated with 50 ng/ml FGF21 for 24 h followed by immunoblotting. (A) Immunoblots. β-actin was used as a control. FGF21 increased the levels Sod2 and Trx2 that are antioxidants localized to mitochondria. (B-C) Quantification. Sod2 (B) and Trx2 (C) increased in FGF21-treated neurons. Values are means ± SD, n = 4, **p < 0.01 or *p < 0.05 for FGF21 vs C.