Isolation and characterization of H9N2 influenza virus isolates from poultry respiratory disease outbreak

Jakhesara, Subhash J; Bhatt, Vaibhav D; Patel, Namrata V; Prajapati, Kantilal S; Joshi, Chaitanya G

doi:10.1186/2193-1801-3-196

SpringerPlus

Table 2 Analysis of mutation at amino acid positions important for host range pathogenicity and virulence

From: Isolation and characterization of H9N2 influenza virus isolates from poultry respiratory disease outbreak

Protein	aa position	Deduced amino acid		Amino acid in isolates from this study	Reference
Protein	aa position	Human	Avian	Amino acid in isolates from this study	Reference
PB2	44	S	A	A	(Chen et al. 2006; Finkelstein et al. 2007; Shaw et al. 2002)
	64	T	M	M	(Finkelstein et al. 2007)
	81	M	T	T	(Shaw et al. 2002)
	199	S	A	A	(Chen et al. 2006; Shaw et al. 2002; Finkelstein et al. 2007)
	256	G	D	D	(Manzoor et al. 2009)
	271	A	T	T	(Chen et al. 2006; Shaw et al. 2002)
	333	I	T	T	(Naffakh et al. 2008)
	355	Q	K	R ^a	(Katz et al. 2000)
	475	M	L	L	(Chen et al. 2006)
	482	R	K	K	(Naffakh et al. 2008)
	588	I	A	V	(Chen et al. 2006; Shaw et al. 2002; Finkelstein et al. 2007)
	613	T	V	V	(Chen et al. 2006; Shaw et al. 2002)
	627	K	E	E	(Chen et al. 2006; Naffakh et al. 2008)
	661	T	A	A	(Shaw et al. 2002)
	674	T	A	A	(Chen et al. 2006; Shaw et al. 2002; Finkelstein et al. 2007)
	701	N	D	D	(Naffakh et al. 2008)
	702	R	K	K	(Shaw et al. 2002)
	714	R	S	S	(Naffakh et al. 2008)
PB1	13	P	L	P	(Naffakh et al. 2008)
	327	K	R	R	(Chen et al. 2006)
	336	1	V	V	(Chen et al. 2006)
	538	G	D	D	(Naffakh et al. 2008)
	578	Q	K	K	(Naffakh et al. 2008)
	678	N	S	S	(Naffakh et al. 2008)
PA	28	L	P	P	(Chen et al. 2006; Shaw et al. 2002)
	55	N	D	D	(Chen et al. 2006; Shaw et al. 2002)
	57	Q	R	Q/R	(Chen et al. 2006; Finkelstein et al. 2007)
	65	L/Y	S	S	(Naffakh et al. 2008; Shaw et al. 2002)
	100	A	V	V	(Shaw et al. 2002)
	133	G	E	E	(Naffakh et al. 2008)
	241	Y	C	Y/C	(Shaw et al. 2002)
	225	C	S	S	(Chen et al. 2006)
	268	I	L	L	(Chen et al. 2006)
NP	16	D	G	G	(Chen et al. 2006)
	31	K	R	R	(Shaw et al. 2002)
	33	I	V	V	(Chen et al. 2006; Shaw et al. 2002)
	34	N	D	G	(Naffakh et al. 2008)
	61	L	I	I	(Chen et al. 2006; Shaw et al. 2002)
	100	V	R	R	(Chen et al. 2006; Shaw et al. 2002)
	109	V	I	I	(Chen et al. 2006)
	127	D	E	E	(Shaw et al. 2002)
	136	M	L	I	(Shaw et al. 2002)
	214	K	R	R	(Chen et al. 2006; Shaw et al. 2002)
	283	P	L	L	(Chen et al. 2006; Shaw et al. 2002)
	319	K	N	N	(Naffakh et al. 2008)
	293	K	R	R	(Chen et al. 2006; Shaw et al. 2002)
	305	K	R	R	(Chen et al. 2006)
	313	Y	F	F	(Chen et al. 2006; Shaw et al. 2002)
	357	K	Q	Q	(Chen et al. 2006; Finkelstein et al. 2007)
	372	D	E	D	(Chen et al. 2006)
	375	G/E	D	D	(Shaw et al. 2002)
	422	K	R	R	(Chen et al. 2006)
	442	A	T	T	(Chen et al. 2006)
	455	E	D	D	(Chen et al. 2006)
	480	N	D	D	(Naffakh et al. 2008)
M1	15	I	V	I	(Katz et al. 2000)
	115	I	V	V	(Chen et al. 2006)
	121	A	T	T	(Chen et al. 2006)
	137	A	T	T	(Shaw et al. 2002)
M2	11	I	T	T	(Chen et al. 2006)
	16	G/D	E	G	(Shaw et al. 2002)
	20	N	S	S	(Chen et al. 2006; Shaw et al. 2002)
	28	I/V	I	F	(Shaw et al. 2002)
	55	F	L	F	(Shaw et al. 2002)
	57	H	Y	Y	(Chen et al. 2006)
	78	K	Q	Q	(Shaw et al. 2002)
	86	A	V	V	(Chen et al. 2006)
NS1	215	T	P	P	(Finkelstein et al. 2007)
	227	R/K	E	K	(Chen et al. 2006; Finkelstein et al. 2007)
NS2	70	G	S	S	(Chen et al. 2006)

^aAmino acids in boldface denotes the change from nucleotide commonly observed in avian associated H9 viruses.

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