Promoter hypermethylation of tumor suppressor genes correlates with tumor grade and invasiveness in patients with urothelial bladder cancer

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Table 3 Normalized index of methylation (NIM)% and corresponding p-values

	*RASSF1A*	*APC*	*MGMT*	*CDKN2A*	*CDKN2B*
Invasive high grade urothelial bladder cancer (n = 33)
Mean	40	6.1	9	0.09	0.58
Range	0-270	0-50	0-96	0-2	0-6
Non-invasive low grade urothelial bladder cancer (n = 43)
Mean	2	2	2.3	0.4	0.1
Range	0-49	0-43	0-41	0-8	0-2
Normal bladder (n = 10)
Mean	2	0	0	1	2
Range	0-12	0	0-4	0-16	0-1
*p-value	<0.001	<0.001	<0.001	0.748	0.114
Plasma samples (n = 16)
Mean	24.9	0.035	16.2	1.5	5.9
Range	3-125	0-4.4	0.1-111.7	0-16.3	0.1-18.9
**p-value	0.539	<0.001	0.524	0.215	<0.01