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Table 3 Normalized index of methylation (NIM)% and corresponding p-values

From: Promoter hypermethylation of tumor suppressor genes correlates with tumor grade and invasiveness in patients with urothelial bladder cancer

  RASSF1A APC MGMT CDKN2A CDKN2B
Invasive high grade urothelial bladder cancer (n = 33)      
 Mean 40 6.1 9 0.09 0.58
 Range 0-270 0-50 0-96 0-2 0-6
Non-invasive low grade urothelial bladder cancer (n = 43)      
 Mean 2 2 2.3 0.4 0.1
 Range 0-49 0-43 0-41 0-8 0-2
Normal bladder (n = 10)      
 Mean 2 0 0 1 2
 Range 0-12 0 0-4 0-16 0-1
*p-value <0.001 <0.001 <0.001 0.748 0.114
Plasma samples (n = 16)      
 Mean 24.9 0.035 16.2 1.5 5.9
 Range 3-125 0-4.4 0.1-111.7 0-16.3 0.1-18.9
**p-value 0.539 <0.001 0.524 0.215 <0.01
  1. *Kruskal Wallis Test **Paired T-Test (p-value<0.01).