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Table 3 Normalized index of methylation (NIM)% and corresponding p-values

From: Promoter hypermethylation of tumor suppressor genes correlates with tumor grade and invasiveness in patients with urothelial bladder cancer

 

RASSF1A

APC

MGMT

CDKN2A

CDKN2B

Invasive high grade urothelial bladder cancer (n = 33)

     

 Mean

40

6.1

9

0.09

0.58

 Range

0-270

0-50

0-96

0-2

0-6

Non-invasive low grade urothelial bladder cancer (n = 43)

     

 Mean

2

2

2.3

0.4

0.1

 Range

0-49

0-43

0-41

0-8

0-2

Normal bladder (n = 10)

     

 Mean

2

0

0

1

2

 Range

0-12

0

0-4

0-16

0-1

*p-value

<0.001

<0.001

<0.001

0.748

0.114

Plasma samples (n = 16)

     

 Mean

24.9

0.035

16.2

1.5

5.9

 Range

3-125

0-4.4

0.1-111.7

0-16.3

0.1-18.9

**p-value

0.539

<0.001

0.524

0.215

<0.01

  1. *Kruskal Wallis Test **Paired T-Test (p-value<0.01).
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