Promoter hypermethylation of tumor suppressor genes correlates with tumor grade and invasiveness in patients with urothelial bladder cancer

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Table 1 Clinicopathological parameters of normal and bladder Cancer FFPE samples

Parameter	Low grade urothelial cancer	High grade urothelial cancer	Normal bladder mucosa
Number of patients	43	33	10
Males	37(86%)	26(78%)	05
Females	06(14%)	07(21%)	05
Age
Median (Inter-quartile range)	64(50-73)	61(53-68)	49(40-59)
Pathologic stage
pTa-pT1	43
≥pT2		33

(pTa: Non-invasive papillary carcinoma, pT1: Tumor invades sub epithelial connective tissue, pT2: Tumor invades muscle, pT3: Tumor invades perivesical tissue, pT4: Tumor invades any of the following: prostate, uterus, vagina, pelvic wall, abdominal wall).