|
Biomarker
|
Intervention arm
|
Baseline
|
Week 34
|
Week 52
|
|---|
|
Geometric mean (95% CI)
|
Geometric mean (95% CI)
|
Geometric mean (95% CI)
|
|---|
| |
Low-fat
|
9.72 (8.11–11.65)
|
9.55 (8.11–11.24)
|
9.36 (7.61–11.52)
|
|
Adiponectin (μg/mL)
|
Low-carbohydrate
|
10.86 (8.90–13.24)
|
10.66 (8.91–12.76)
|
10.44 (8.31–13.13)
|
| |
Overall
|
10.27 (8.98–11.75)
|
10.09 (8.94–11.39)
|
9.89 (8.47–11.54)
|
|
Leptin (ng/mL)a
|
Low-fat
|
25.93 (20.38–32.98)
|
17.07 (13.54–21.52)
|
18.85 (14.13–25.16)
|
|
Low-carbohydrate
|
31.56 (24.61–40.47)
|
20.52 (15.80–26.64)
|
20.87 (14.47–30.10)
|
|
Overall
|
28.61 (24.06–34.01)
|
18.85 (15.30–15.30)
|
19.83 (15.71–25.04)
|
|
A/L ratiob
|
Low-fat
|
0.40 (0.30–0.54)
|
0.46 (0.36–0.59)
|
0.54 (0.38–0.77)
|
|
Low-carbohydrate
|
0.35 (0.26–0.49)
|
0.44 (0.34–0.58)
|
0.57 (0.38–0.85)
|
|
Overall
|
0.38 (0.30–0.47)
|
0.45 (0.37–0.54)
|
0.55 (0.42–0.72)
|
- NOTE: Mixed models with repeated measurements of natural log transformed serum adipokine concentrations were used. Overall estimates are averages across the two diets. Estimates for leptin assume a quadratic trend in time. All other estimates assume a linear trend in time. Data presented correspond to geometric means and 95% CIs. No difference in trend by diet was observed for any biomarker.
- aBorderline significant quadratic trend was observed for serum leptin (P = 0.05); no difference observed between baseline and Week 52 serum leptin concentrations (P > 0.05).
- bAverage trend in time across diets was significant (P = 0.02). Significant difference observed between baseline and Week 52 for the A/L ratio for low-carbohydrate diet (P = 0.05).
