|
Biomarker
|
Intervention arm
|
Baseline
|
Week 34
|
Week 52
|
|---|
|
Geometric mean (95% CI)
|
Geometric mean (95% CI)
|
Geometric mean (95% CI)
|
|---|
| |
Low-fat
|
11.93 (8.13–17.50)
|
10.11 (7.02–14.57)
|
8.39 (4.85–14.53)
|
|
Adiponectin (μg/mL)
|
Low-carbohydrate
|
11.06 (7.53–16.25)
|
11.55 (8.20–16.27)
|
12.11 (7.69–19.09)
|
| |
Overall
|
11.49 (8.76–15.07)
|
10.80 (8.41–13.88)
|
10.08 (7.06–14.40)
|
|
Leptin (ng/mL)
|
Low-fat
|
28.21 (16.76–47.50)
|
22.21 (12.80–38.54)
|
22.97 (7.95–66.37)
|
|
Low-carbohydrate
|
29.12 (17.24–49.18)
|
25.34 (14.92–43.04)
|
20.36 (9.41–44.06)
|
|
Overall
|
28.66 (19.81–41.48)
|
24.65 (16.00–37.97)
|
21.62 (11.23–41.65)
|
|
A/L ratio
|
Low-fat
|
0.43 (0.23–0.80)
|
0.42 (0.23–0.76)
|
0.41 (0.16–1.06)
|
|
Low-carbohydrate
|
0.38 (0.20–0.71)
|
0.46 (0.27–0.80)
|
0.58 (0.27–1.25)
|
|
Overall
|
0.40 (0.26–0.63)
|
0.44 (0.29–0.66)
|
0.49 (0.27–0.90)
|
- NOTE: Mixed models with repeated measurements of natural log transformed serum adipokine concentrations were used. Overall estimates are averages across the two diets. Estimates for leptin assume a quadratic trend in time. All other estimates assume a linear trend in time. Data presented correspond to geometric means and 95% CIs. No difference in trend by diet was observed for any biomarker.
