|
Biomarker
|
Intervention arm
|
Baseline
|
Week 34
|
Week 52
|
|---|
|
Geometric mean (95% CI)
|
Geometric mean (95% CI)
|
Geometric mean (95% CI)
|
|---|
| |
Low-fat
|
10.41 (8.87–12.22)
|
9.98 (8.62–11.56)
|
9.52 (7.83–11.58)
|
|
Adiponectin (μg/mL)
|
Low-carbohydrate
|
11.03 (9.32–13.05)
|
10.77 (9.21–12.58)
|
10.48 (8.50–12.91)
|
| |
Overall
|
10.72 (9.54–12.03)
|
10.37 (9.31–11.54)
|
9.99 (8.66–11.52)
|
|
Leptin (ng/mL)a
|
Low-fat
|
28.37 (22.72–35.43)
|
19.90 (15.73–25.18)
|
21.85 (16.21–29.45)
|
|
Low-carbohydrate
|
31.82 (25.34–39.95)
|
20.60 (15.99–26.54)
|
25.56 (18.02–36.24)
|
|
Overall
|
30.05 (25.63–35.23)
|
19.80 (16.25–24.14)
|
23.63 (18.78–29.73)
|
|
A/L ratiob
|
Low-fat
|
0.38 (0.29–0.51)
|
0.42 (0.33–0.54)
|
0.47 (0.33–0.68)
|
|
Low-carbohydrate
|
0.36 (0.27–0.49)
|
0.43 (0.33–0.56)
|
0.52 (0.35–0.76)
|
|
Overall
|
0.37 (0.30–0.46)
|
0.43 (0.35–0.51)
|
0.50 (0.38–0.64)
|
- NOTE: Mixed models with repeated measurements of natural log transformed serum adipokine concentrations were used.
- Overall estimates are averages across the two diets. Estimates for leptin assume a quadratic trend in time. All other estimates assume a linear trend in time. Data presented correspond to geometric means and 95% CIs. No difference in trend by diet was observed for any biomarker.
- aSignificant quadratic trend was observed for serum leptin (P = 0.01); no difference observed between baseline and Week 52 serum leptin concentrations (P > 0.05).
- bAverage trend in time across diets was borderline significant for serum A/L ratio (P = 0.05).
