Figure 1

IAC treatment partially prevented serum creatinine levels increase, body weight loss and acute tubular necrosis after I/R induction. (A) Untreated control (CTRL) mice showed at day (D) 1 and D2 a more significant increase in serum creatinine levels after the induction of ischemia/reperfusion compared to non-peptidyl low molecular weight radical scavenger (IAC)-treated mice (D1 and D2: CTRL vs. IAC-treated, *p < 0.05). (B) Untreated CTRL mice showed a progressive and more evident reduction of body weight after ischemia/reperfusion induction compared to IAC-treated mice (D1, D2 and D4: CTRL vs. IAC-treated, *p < 0.05). (C) Untreated CTRL mice showed acute tubular necrosis signs in kidneys outer medulla with hyaline and granular casts accumulation. (D) Conversely, the extent of acute tubular necrosis was reduced in IAC-treated mice.