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Table 3 Association between baseline factors and change in ALT following fibrate treatment

From: Effect of fibrate treatment on liver function tests in patients with the metabolic syndrome

Model 1: linear regression analysis with change in ALT as the dependent variable and the following as independent variables in separate analyses

Ā 

n

Co-efficient

95% C.I.

p-value

Pre fibrate GGT

114

āˆ’0.1

āˆ’0.15- ā€“0.05

<0.001

Pre fibrate ALT

114

āˆ’0.36

āˆ’0.43- ā€“0.28

<0.001

Model 2: multiple regression analysis with change in ALT as the dependent variable and the following as independent variables in a single analysis.

Ā 

n

Co-efficient

95% C.I.

p-value

Pre fibrate GGT

114 (r2 = 0.45)

āˆ’0.03

āˆ’0.08-0.012

0.16

Pre fibrate ALT

āˆ’0.33

āˆ’0.41- ā€“0.25

<0.001

  1. Age, gender, pre-fibrate lipids (TC, TG & HDL-C), pre-fibrate ALP, pre-fibrate creatinine, treatment duration and changes in lipids (TC, TG & HDL-C) were not significantly associated with changes observed in ALT following fibrate treatment.