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Table 2 Diagnostic accuracy of methylene blue in the study groups

From: Methylene blue as an early diagnostic marker for oral precancer and cancer

Methylene Blue Retention Histological diagnosis Overall (PML + SCC)
Premalignant Lesion (PML) Squamous Cell Carcinoma (SCC)
Dysplasia Hyperkeratosis without dysplasia OSCC No evidence of malignancy
+ 42 1 44 1  
4 3 4 1  
Sensitivity 91.3% 91.6% 91.4%
Specificity 75% 50% 66.6%
Positive predictive value 97.6% 97.7% 97.7%
Negative Predictive Value 42.8% 20% 33.3%
Diagnostic Accuracy 90% 90% 90% p < 0.0001(very significant)