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Table 4 A summary of in vitro immunomodulatory screening of the endophytic fungal extracts by the lymphocyte proliferation assay

From: Identification and bioactive potential of endophytic fungi isolated from selected plants of the Western Himalayas

S.No. Test Extract Dose μg/ml Immunomodulatory activity (% lymphocyte proliferation) Inhibition (↓) /stimulation (↑)
  Cont   T -Cell B-Cell
   - - -
1. K1 1 34↓* 54↓**
   10 31↓ 22↓
2. K2 1 15 46↑
   10 12 49↑
3. K4 1 31↑ 40↑
   10 42↑ 57↑
4. K7 1 40↓** 37↓*
   10 25↓ 46↓**
5. DEF3 1 32↑ 65↑**
   10 37↑ 48↑
6. DEF4 1 34↓ 51↓
   10 34↓ 44↓
7. Art 1 28↑ 47↑
   10 33↑ 22↑
8. Art3 1 44↓* 38↓*
   10 37↓* 52↓**
9. Art4 1 25↓ 51↓
   10 40↓** 45↓**
10. FEF2 1 56↑ 40↑*
   10 29↑ 47↑**
11. FEF4 1 57↑** 11
   10 62↑** 18
12. NF2 1 14↑ 32↑*
   10 28↑ 45↑
13. PR1 1 51↑** 19↑
   10 34↑ 14↑
14. PR2 1 15↑ 48↑**
   10 28↑ 34↑
15. PR3 1 48↑ 43↑
   10 28↑ 54↑**
16. PR4 1 25↑ 15↑
   10 16↑ 44↑*
Betamethasone 0.005 46↓ 34↓
Levamisole 0.05 29↑ 43↑
  1. 16 extracts demonstrated significant immune-modulation. Levamisole (as stimulator) and Betamethasone (as an immunesuppressor) were used as positive controls. Data are presented as % inhibition or stimulation of sets of independent experiments. * P<0.05 and ** P<0.01 represent significant difference compared with cells treated with Levamisole and Betamethasone.