Figure 4

Typical mitochondrial redox state and Pyro-2DG uptake images and their corresponding histograms of a representative section of a large MCF-7 tumor (>10 mm, Vol = 568 mm³). The Fp redox ratio, NADH redox ratio, and normalized Pyro-2DG (Pyro-2DG/(Fp + NADH)) range between 0 and 1. The Fp, NADH, and Pyro-2DG images are in the unit of μM in reference to the corresponding standards. For other notations see the legend of Figure 1.