Figure 1

Typical images of redox scanning of the mouse xenografts of MCF-7 (left, depth d = 3400 μm), MDA-MB-468 (middle d = 1200 μm), and MDA-MB-231 (right, d = 800 μm) tumor lines. The Fp or NADH redox ratio ranges between 0 and 1; the Fp or NADH images are in the unit of μM in reference to the corresponding standards. The x axes of the corresponding histograms represent the Fp redox ratio or concentration. The y axes represent the number of pixels in the tumor section having a specific value of Fp redox ratio or Fp and NADH concentration. The small round spots outside the tumor section are the images of Fp or NADH reference standards. The images are labeled with numbers on the bottom and left axes to indicate the positions of the image matrices with a spatial resolution of 200 μm.