Table 3 Laboratory data of patients with acetaminophen poisoning (N = 187)
From: Outcomes of patients with acetaminophen-associated toxic hepatitis at a far east poison center
Variable | Total (N = 187) | No toxic hepatitis (N = 172) | Toxic hepatitis (N = 15) | P value |
|---|---|---|---|---|
First day (arrival) | ||||
Hemoglobin (g/dL) | 13.4 ± 1.5 | 13.4 ± 1.5 | 13.6 ± 1.3 | 0.589 |
Neutrophils (/μL) | 9078.7 ± 4077.6 | 8747.5 ± 3271.6 | 10305.4 ± 6123.8 | <0.001*** |
Platelet (103/μL) | 246.3 ± 68.9 | 250.9 ± 61.9 | 196.5 ± 111.7 | 0.006 |
Urea nitrogen (mg/dL) | 8.8 ± 4.5 | 8.9 ± 4.6 | 7.6 ± 3.4 | 0.542 |
Creatinine (mg/dL) | 0.8 ± 0.2 | 0.7 ± 0.2 | 0.8 ± 0.3 | 0.060 |
Sodium | 140.1 ± 3.2 | 140.2 ± 3.2 | 139.1 ± 2.5 | 0.180 |
Potassium | 3.6 ± 1.6 | 3.6 ± 1.7 | 3.3 ± 0.4 | 0.584 |
AST (U/L) | 146.1 ± 1125.7 | 31.1 ± 34.4 | 1497.6 ± 3915.7 | <0.001*** |
ALT (U/L) | 75.4 ± 380.6 | 23.6 ± 31.9 | 720.7 ± 1264.8 | <0.001*** |
Total bilirubin (mg/dL) | 1.0 ± 0.5 | 0.9 ± 0.4 | 1.7 ± 1.0 | <0.001*** |
Albumin (g/dL) | 4.0 ± 0.7 | 4.1 ± 0.6 | 3.6 ± 0.7 | 0.588 |
Prothrombin time (INR, sec) | 1.2 ± 0.4 | 1.1 ± 0.1 | 2.0 ± 0.9 | 0.000*** |
γ-glutamyl transferase (U/L) | 75.6 ± 107.3 | 39.6 ± 61.5 | 290.1 ± 16.3 | 0.327 |
Alkaline phosphatase (U/L) | 51.6 ± 19.2 | 47.7 ± 16.4 | 70.1 ± 21.9 | 0.433 |
Ammonia | 81.0 ± 67.6 | 54.5 ± 29.6 | 137.6 ± 92.0 | 0.010 |
Second day | ||||
AST (U/L) | 503.1 ± 2005.0 | 37.4 ± 75.9 | 3962.7 ± 4637.8 | <0.001*** |
ALT (U/L) | 377.0 ± 1254.8 | 47.1 ± 117.2 | 3148.5 ± 2532.4 | <0.001*** |
Total bilirubin (mg/dL) | 1.2 ± 1.3 | 0.9 ± 0.6 | 2.9 ± 2.4 | <0.001*** |
Prothrombin time (INR, sec) | 1.1 ± 0.1 | 2.4 ± 0.8 | <0.001*** | |
Fourth day | ||||
AST (U/L) | 302.4 ± 931.7 | 35.5 ± 63.2 | 1575.4 ± 1791.3 | <0.001*** |
ALT (U/L) | 343.0 ± 1035.4 | 56.4 ± 126.4 | 2745.4 ± 1915.3 | <0.001*** |
Total bilirubin (mg/dL) | 0.9 ± 0.8 | 0.7 ± 0.5 | 1.8 ± 1.3 | <0.001*** |
Prothrombin time (INR, sec) | 1.1 ± 0.1 | 1.9 ± 0.8 | <0.001*** |