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Table 3 Laboratory data of patients with acetaminophen poisoning (N = 187)

From: Outcomes of patients with acetaminophen-associated toxic hepatitis at a far east poison center

Variable Total (N = 187) No toxic hepatitis (N = 172) Toxic hepatitis (N = 15) P value
First day (arrival)     
Hemoglobin (g/dL) 13.4 ± 1.5 13.4 ± 1.5 13.6 ± 1.3 0.589
Neutrophils (/μL) 9078.7 ± 4077.6 8747.5 ± 3271.6 10305.4 ± 6123.8 <0.001***
Platelet (103/μL) 246.3 ± 68.9 250.9 ± 61.9 196.5 ± 111.7 0.006
Urea nitrogen (mg/dL) 8.8 ± 4.5 8.9 ± 4.6 7.6 ± 3.4 0.542
Creatinine (mg/dL) 0.8 ± 0.2 0.7 ± 0.2 0.8 ± 0.3 0.060
Sodium 140.1 ± 3.2 140.2 ± 3.2 139.1 ± 2.5 0.180
Potassium 3.6 ± 1.6 3.6 ± 1.7 3.3 ± 0.4 0.584
AST (U/L) 146.1 ± 1125.7 31.1 ± 34.4 1497.6 ± 3915.7 <0.001***
ALT (U/L) 75.4 ± 380.6 23.6 ± 31.9 720.7 ± 1264.8 <0.001***
Total bilirubin (mg/dL) 1.0 ± 0.5 0.9 ± 0.4 1.7 ± 1.0 <0.001***
Albumin (g/dL) 4.0 ± 0.7 4.1 ± 0.6 3.6 ± 0.7 0.588
Prothrombin time (INR, sec) 1.2 ± 0.4 1.1 ± 0.1 2.0 ± 0.9 0.000***
γ-glutamyl transferase (U/L) 75.6 ± 107.3 39.6 ± 61.5 290.1 ± 16.3 0.327
Alkaline phosphatase (U/L) 51.6 ± 19.2 47.7 ± 16.4 70.1 ± 21.9 0.433
Ammonia 81.0 ± 67.6 54.5 ± 29.6 137.6 ± 92.0 0.010
Second day     
AST (U/L) 503.1 ± 2005.0 37.4 ± 75.9 3962.7 ± 4637.8 <0.001***
ALT (U/L) 377.0 ± 1254.8 47.1 ± 117.2 3148.5 ± 2532.4 <0.001***
Total bilirubin (mg/dL) 1.2 ± 1.3 0.9 ± 0.6 2.9 ± 2.4 <0.001***
Prothrombin time (INR, sec)   1.1 ± 0.1 2.4 ± 0.8 <0.001***
Fourth day     
AST (U/L) 302.4 ± 931.7 35.5 ± 63.2 1575.4 ± 1791.3 <0.001***
ALT (U/L) 343.0 ± 1035.4 56.4 ± 126.4 2745.4 ± 1915.3 <0.001***
Total bilirubin (mg/dL) 0.9 ± 0.8 0.7 ± 0.5 1.8 ± 1.3 <0.001***
Prothrombin time (INR, sec)   1.1 ± 0.1 1.9 ± 0.8 <0.001***
  1. Note: ***P < 0.001.