Figure 5

Effects of sesame oil on NF-κB activity and IL-4 level in isolated mast cell in MSU crystal-treated rats. To investigate mast cell degranulation in sesame oil-treated gout, NF-κB activity (A) and IL-4 level (B) were assessed. Rats were divided into four groups of six: Group I, negative control group; Group II, rats were received sesame oil (4 mL/kg, orally) alone; Group III, rats were injected MSU crystal (5 mg/rat) into air pouch; and Group IV, rats were given sesame oil 6 h after MSU crystal injection. NF-κB activity and IL-4 level in mast cells isolated from surrounding tissue were assessed 12 h after MSU crystal injection. Data are means ± SD (n = 6). Significant differences between groups were analyzed using one-way ANOVA. Different letters above the bars indicate significant (P < 0.05) differences.