Enhanced glycemic control, pancreas protective, antioxidant and hepatoprotective effects by umbelliferon-α-D-glucopyranosyl-(2I → 1II)-α-D-glucopyranoside in streptozotocin induced diabetic rats

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Table 4 Effect UFD on antioxidant enzyme at end of the study

S. No.	Biochemical parameter	Normal control	Normal control + UFG (40 mg/kg)	STZ-diabetic control^a	STZ diabetes + UFD (10 mg/kg)^b	STZ diabetes + UFD (20 mg/kg)^b	STZ diabetes + UFD (40 mg/kg)^b	STZ diabetes + Glibenclamide (10 mg/kg)^b
1	SOD (U/mg of protein)	207.8 ± 1.985	206.6 ± 1.077	71.8 ± 2.691^***	147.8 ± 2.177^*	177.8 ± 3.955^**	193.2 ± 3.247^***	191.6 ± 2.421^***
2	CAT (U/mg of protein)	135.8 ± 1.855	135.4 ± 2.358	57 ± 1.517^***	79.8 ± 1.985^*	100.8 ± 1.934^*	122.4 ± 2.015^***	118.8 ± 0.861^***
3	GPx (nmole/mg of protein)	34.4 ± 1.077	34.8 ± 1.241	14 ± 0.707^***	22.4 ± 0.509^*	26.4 ± 0.562^**	32 ± 0.712^***	29.6 ± 0.514^***
4	MDA (nmole/mg of protein)	0.212 ± 0.008	0.218 ± 0.009	0.526 ± 0.011^***	0.431 ± 0.013^*	0.331 ± 0.012^**	0.251 ± 0.007^***	0.294 ± 0.005^***

All values represent mean ± SEM * P < 0.05; ** P < 0.01; *** P < 0.001, ns < non significant; ANOVA, followed by Dunnett’s multiple comparison test.
^aCompared to vehicle control.
^bCompared to diabetic control.