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Table 5 Frequency distribution of SNPs between cases and controls using the dominant coding scheme

From: Adiposity, inflammation, genetic variants and risk of post-menopausal breast cancer findings from a prospective-specimen-collection, retrospective-blinded-evaluation (PRoBE) design approach

Gene, chromosomal location

SNP

Genotype

Controls

Cases

P-value

N (%)

N (%)

FTO, 16 q12.2

rs9939609

A/A and A/T

513 (71.35)

122 (72.62)

0.74

T/T

206 (28.65)

46 (27.38)

rs1861868

C/C and C/T

526 (78.39)

123 (76.88)

0.68

T/T

145 (21.61)

37 (23.13)

rs1477196

G/G and A/G

582 (82.32)

135 (82.82)

0.88

A/A

125 (17.68)

28 (17.18)

PTGS2, 1q25.2-25.3

rs2745559

C/C and A/C

632 (95.04)

157 (96.91)

0.31

A/A

33 (4.96)

5 (3.09)

rs689466

T/T and C/T

483 (69.90)

112 (69.14)

0.85

C/C

208 (30.10)

50 (30.86)

rs689470

G/G and A/G

617 (86.90)

153 (90.53)

0.20

A/A

93 (13.10)

16 (9.47)

Rs2206593

G/G and A/G

602 (83.50)

150 (86.71)

0.30

A/A

119 (16.50)

23 (13.29)

rs5277

C/C and C/G

656 (97.33)

155 (98.73)

0.30

G/G

18 (2.67)

2 (1.27)

rs12042763

G/G and G/T

565 (87.73)

134 (86.45)

0.67

T/T

79 (12.27)

21 (13.55)

rs2383529

A/A and A/G

611(94.58)

150 (96.15)

0.42

G/G

35 (5.42)

6 (3.85)

FGGR2, 10q26

rs1219648

A/A and A/G

571 (85.61)

134 (84.28)

0.67

G/G

96 (14.39)

25 (15.72)

rs11200014

G/G and A/G

608 (87.11)

131 (82.39)

0.12

A/A

90 (12.89)

28 (17.61)

rs2981582

G/G and A/G

581 (85.69)

128 (81.53)

0.19

A/A

97 (14.31)

29 (18.47)

GHRL, 3q26.3

rs171336

G/G and G/T

617 (87.64)

148 (90.24)

0.35

T/T

87 (12.36)

16 (9.76)

rs171407

A/A and A/G

554 (80.06)

128 (83.12)

0.39

G/G

138 (19.94)

26 (16.88)

rs35684

A/A and A/G

663 (92.73)

159 (95.21)

0.25

G/G

52 (7.27)

8 (4.79)

rs4684677

T/T and A/T

699 (99.86)

163 (100.00)

0.63

A/A

1 (0.14)

0 (0.00)

rs2075356

T/T and C/T

629 (87.48)

148 (91.93)

0.11

T/T

90 (12.52)

13 (8.07)

rs27647

T/T and C/T

572 (82.18)

142 (87.65)

0.09

C/C

124 (17.82)

20 (12.35)

rs3755777

C/C and C/G

641 (94.40)

152 (94.41)

0.99

G/G

38 (5.60)

9 (5.59)

rs27498

G/G and A/G

604 (87.03)

148 (88.10)

0.71

A/A

90 (12.97)

20 (11.90)

rs10490815

T/T and C/T

606 (93.09)

140 (92.72)

0.87

C/C

45 (6.91)

11 (7.28)

GHSR, 3q26.2

rs2948694

A/A and A/G

708 (98.33)

163 (98.79)

0.67

G/G

12 (1.67)

2 (1.21)

rs2922126

T/T and A/T

597 (88.18)

158 (95.18)

0.008 1

A/A

80 (11.82)

8 (4.82)

IL6, 7p21.0

rs4552807

T/T and A/T

527 (76.16)

128 (75.74)

0.91

A/A

165 (23.84)

41 (24.26)

rs6969502

G/G and A/G

674 (95.33)

158 (94.61)

0.70

A/A

33 (4.67)

9 (5.39)

rs6952003

T/T and A/T

629 (94.44)

147 (94.23)

0.92

A/A

37 (5.56)

9 (5.77)

rs10156056

G/G and C/G

655 (98.05)

153 (98.71)

0.58

C/C

13 (1.95)

2 (1.29)

rs7776857

T/T and G/T

637 (88.23)

150 (92.02)

0.16

G/G

85 (11.77)

13 (7.98)

rs7801617

G/G and A/G

631 (88.50)

158 (93.49)

0.06

A/A

82 (11.50)

11 (6.51)

rs7805828

A/A and A/G

606 (87.57)

133 (83.13)

0.13

G/G

86 (12.43)

27 (16.88)

rs12700386

C/C and C/G

695 (96.80)

161 (96.99)

0.90

G/G

23 (3.20)

5 (3.01)

rs1800795

C/C and G/C

569 (81.40)

144 (87.80)

0.05 1

G/G

130 (18.60)

20 (12.20)

rs2069840

C/C and C/G

633 (90.56)

151 (89.88)

0.79

G/G

66 (9.44)

17 (10.12)

rs10242595

G/G and A/G

613 (89.75)

143 (91.08)

0.62

A/A

70 (10.25)

14 (8.92)

rs11766273

G/G and A/G

691(98.29)

159 (100.00)

0.097

A/A

12 (1.71)

0 (0.00)

MAP3K1, 5q11.2

rs889312

A/A and A/C

679 (94.31)

143 (86.14)

< 0.001 1

C/C

41 (5.69)

23 (13.86)

 

ESR1, 6q25.1

rs2046210

G/G and A/G

573 (83.77)

139 (84.24)

0.88

A/A

111 (16.23)

26 (15.76)

rs12662670

T/T and G/T

631 (92.25)

152 (95.00)

0.23

G/G

53 (7.75)

8 (5.00)

rs3020314

T/T and C/T

564 (80.34)

134 (83.75)

0.32

C/C

138 (19.66)

26 (16.25)

  1. 1Genotype distributions between cases and controls were statistically significant.