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Table 1 Correlation of UGT1A4, MRP and ERα in HepG2 and MCf7 Cell lines: Correlation analysis of MCF7/HepG2 UGT1A4 mRNA expression level with its own UGT1A4 protein, Anastrozole glucuronidation, ERα mRNA, ERα protein, MRP 1, MRP 2 and MRP 3

From: Fulvestrant up regulates UGT1A4 and MRP s through ERα and c-Myb pathways: a possible primary drug disposition mechanism

 

MCF-7 UGT1A4 mRNA

HepG2-UGT1A4 mRNA

MCF7/HepG2 UGT1A4 protein

0.969**

0.999**

MCF7/HepG2 Anastrozole glucuronidation

0.875*

0.961**

MCF7/HepG2 ERα-mRNA

0.915*

0.923**

MCF7/HepG2 ERα-protein

0.760*

0.753

MCF7/HepG2 MRP 1

0.972**

NA

MCF7/HepG2 MRP 2

0.906*

0.948**

MCF7/HepG2 MRP 3

0.983**

0.967**

  1. **p < 0.01; *p < 0.05.
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